SP-D 蛋白, Mouse (HEK293, His)

SP-D Protein (SP-D) enhances lung defense against microorganisms, antigens, and toxins. It interacts with lipopolysaccharides, oligosaccharides, and fatty acids, influencing immune responses. SP-D is involved in pulmonary surfactant turnover, maintaining lung homeostasis. It has a strong affinity for maltose residues and alpha-glucosyl moieties. Structurally, SP-D forms an oligomeric complex of homotrimers for effective pulmonary defense. SP-D Protein, Mouse (HEK293, His) is the recombinant mouse-derived SP-D protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SP-D Protein, Mouse (HEK293, His) is 355 a.a., with molecular weight of 42-46 kDa.

表面活性蛋白 D (SP-D) 在增强肺部防御吸入微生物、有机抗原和毒素的防御机制方面发挥着至关重要的作用。这种多面蛋白质与各种化合物相互作用，包括细菌脂多糖、寡糖和脂肪酸，从而调节免疫系统中的白细胞反应。此外，SP-D 参与肺表面活性物质的细胞外重组或周转，有助于维持肺稳态。值得注意的是，SP-D 对麦芽糖残基和其他 α-葡萄糖基部分表现出强大的亲和力。在结构上，它形成由四组同源三聚体组成的寡聚复合物，强调了其在肺部防御过程中的复杂组织。

Mouse

HEK293

C-6*His

P50404 (A20-F374)

20390  [NCBI]

AEMKSLSQRSVPNTCTLVMCSPTENGLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLQGPTGPVGPKGENGSAGEPGPKGERGLSGPPGLPGIPGPAGKEGPSGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSTGAKGSTGPKGERGAPGVQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGVPGDRGIKGESGLPDSAALRQQMEALKGKLQRLEVAFSHYQKAALFPDGRSVGDKIFRTADSEKPFEDAQEMCKQAGGQLASPRSATENAAIQQLITAHNKAAFLSMTDVGTEGKFTYPTGEPLVYSNWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF

42-46 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 7.4 .

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.