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  4. SWSAP1 蛋白, Human (His)

SWSAP1 蛋白, Human (His)

目录号: HY-P71347
产品使用指南

SWSAP1 是一种由单链 DNA 选择性激活的 ATP 酶，对于同源重组修复 (HRR) 至关重要。除了 ATP 酶活性外，SWSAP1 还独立结合 DNA。与ZSWIM7配合，形成HRR关键复合体，相互稳定。SWSAP1 与关键的 HRR 蛋白（RAD51、RAD51B、RAD51C、RAD51D 和 XRCC3）相互作用，强调了其在促进同源重组修复过程中的作用。SWSAP1 蛋白, Human (His) 是重组的 SWSAP1 蛋白，由 E. coli 表达，带有 N-6*His 标签。SWSAP1 蛋白, Human (His) 全长 229 个氨基酸，分子量约为 ~30.0 kDa。

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描述

SWSAP1, an ATPase selectively activated by single-stranded DNA, is vital for homologous recombination repair (HRR). In addition to ATPase activity, SWSAP1 independently binds DNA. Teaming up with ZSWIM7, it forms a complex crucial for HRR, with mutual stabilization. SWSAP1 interacts with key HRR proteins—RAD51, RAD51B, RAD51C, RAD51D, and XRCC3—underscoring its role in facilitating homologous recombination repair processes. SWSAP1 Protein, Human (His) is the recombinant human-derived SWSAP1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SWSAP1 Protein, Human (His) is 229 a.a., with molecular weight of ~30.0 kDa.
研究背景

ATPase SWSAP1 受到单链 DNA 的选择性刺激，在同源重组修复 (HRR) 中发挥着至关重要的作用。除了 ATP 酶活性外，SWSAP1 还表现出独立的 DNA 结合能力。它与 ZSWIM7 形成功能复合物，有助于同源重组修复，并且两种蛋白质相互稳定。SWSAP1 进一步与 HRR 中涉及的关键蛋白相互作用，包括 RAD51、RAD51B、RAD51C、RAD51D 和 XRCC3，突出显示其参与促进同源重组修复过程。
种属

Human
表达系统

E. coli
标签

N-6*His
蛋白编号

Q6NVH7 (M1-P229)
基因 ID

126074  [NCBI]
蛋白结构
N-term
6*His
SWSAP1 (M1-P229)
Accession # Q6NVH7
C-term
同用名
ATPase SWSAP1; SWIM-type zinc finger 7-associated protein 1; SWS1-associated protein 1; ZSWIM7-associated protein 1; SWSAP1; C19orf39
氨基酸序列

MPAAGPPLLLLGTPGSGKTALLFAAALEAAGEGQGPVLFLTRRPLQSMPRGTGTTLDPMRLQKIRFQYPPSTRELFRLLCSAHEAPGPAPSLLLLDGLEEYLAEDPEPQEAAYLIALLLDTAAHFSHRLGPGRDCGLMVALQTQEEAGSGDVLHLALLQRYFPAQCWLQPDAPGPGEHGLRACLEPGGLGPRTEWWVTFRSDGEMMIAPWPTQAGDPSSGKGSSSGGQP

分子量

Approximately 30.0 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

SWSAP1 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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