Tau/MAPT 蛋白, Macaca mulatta (HEK293, His)

Tau/MAPT Protein crucially promotes microtubule assembly and stability, essential for neuronal polarity. Structurally, its C-terminus binds axonal microtubules, and the N-terminus engages neural plasma membrane components, suggesting a role as a linker protein connecting microtubules to the plasma membrane. Tau's localization dictates axonal polarity, particularly near the centrosome. Short isoforms offer cytoskeletal plasticity, while longer isoforms stabilize microtubules. Tau interacts with proteins like MARK1, MARK2, SQSTM1, and LRP1, revealing its multifaceted role in cellular processes. Tau/MAPT Protein, Macaca mulatta (HEK293, His) is the recombinant Rhesus Macaque-derived Tau/MAPT protein, expressed by HEK293, with N-10*His labeled tag. The total length of Tau/MAPT Protein, Macaca mulatta (HEK293, His) is 458 a.a., with molecular weight of 50.6 kDa.

Tau/MAPT 蛋白通过促进微管组装和稳定性，有助于神经元极性的建立和维持，在细胞动力学中发挥着至关重要的作用。其结构组织揭示了功能二元性，C 末端与轴突微管结合，N 末端与神经质膜成分结合。这种排列表明 tau 蛋白充当连接蛋白，在神经元的微管和质膜之间架起桥梁。tau 在神经元细胞内的定位决定了轴突极性，特别是在中心体定义的区域。值得注意的是，短亚型提供细胞骨架可塑性，而较长亚型可能在稳定性方面发挥优先作用。Tau 参与与各种蛋白质的相互作用网络，包括 MARK1、MARK2、MARK3、MARK4、SQSTM1、PSMC2、FKBP4、CSNK1D、SGK1、PIN1 和 LRRK2，说明其在细胞过程中的多方面参与。此外，它与 LRP1 的相互作用导致内吞作用，凸显了控制 tau 功能多功能性的复杂调节机制。

Rhesus Macaque

HEK293

N-10*His

P57786 (A2-L459)

574327  [NCBI]

AEPRQEFDVMEDHAGTYGLGDRKDQEGYTMLQDQEGDTDAGLKESPLQTPAEDGSEELGSETSDAKSTPTAEDVTAPLVDERAPGEQAAAQPHMEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSATKQVQRKPPPAEPTSERGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPAREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

50.6 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.