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  3. TIM-1/KIM-1/HAVCR 蛋白, Rat (HEK293, His-Fc)

TIM-1/KIM-1/HAVCR 蛋白, Rat (HEK293, His-Fc)

目录号: HY-P73601
产品使用指南

TIM-1/KIM-1/HAVCR蛋白是一种磷脂酰丝氨酸受体,在调节性B细胞中发挥着至关重要的调节作用,影响其生成、扩增和抑制功能。它充当 P-选择素/SELPLG 的配体,并在炎症反应期间控制激活的 T 细胞运输。TIM-1/KIM-1/HAVCR 蛋白, Rat (HEK293, His-Fc) 是重组的 TIM-1/KIM-1/HAVCR 蛋白,由 HEK293 表达,带有 N-hFc, C-His 标签。TIM-1/KIM-1/HAVCR 蛋白, Rat (HEK293, His-Fc) 全长 221 个氨基酸,分子量为 90-100 kDa。

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描述

TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that plays a crucial regulatory role in regulatory B cells, affecting their generation, expansion and inhibitory functions. It acts as a ligand for P-selectin/SELPLG and controls activated T cell trafficking during inflammatory responses. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) is the recombinant rat-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-hFc, C-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) is 221 a.a., with molecular weight of 90-100 kDa.

研究背景

TIM-1/KIM-1/HAVCR 蛋白作为磷脂酰丝氨酸受体,在调节 B 细胞的稳态中发挥着至关重要的功能作用,影响其生成、扩增和抑制功能。此外,作为 P-选择素/SELPLG 的配体,它在炎症反应过程中活化 T 细胞的运输中发挥特殊作用,特别是控制发炎中枢神经系统中 T 细胞的积累并影响自身免疫性疾病的诱导。TIM-1/KIM-1/HAVCR 还调节各种抗炎细胞因子和共抑制配体(包括 IL10)的表达,充当 T 细胞增殖的调节剂。此外,它可能在肾脏损伤和修复中发挥作用。与 STAM 和 SELPLG 的相互作用有助于 TIM-1/KIM-1/HAVCR 蛋白的多方面调节功能。

种属

Rat

表达系统

HEK293

标签

N-hFc;C-His

蛋白编号

O54947 (S18-V238)

基因 ID

286934  [NCBI]

蛋白结构
N-term
hFc
TIM-1 (S18-V238)
Accession # O54947
His
C-term
同用名
Hepatitis A virus cellular receptor 1; HAVcr-1; KIM-1; TIM-1; CD365; HAVCR1
分子量

90-100 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc)
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HY-P73601
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