TIM-1/KIM-1/HAVCR 蛋白, Mouse (HEK293, C-His)

The TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that is critical for B cell homeostasis, affecting generation, expansion, and inhibitory functions. As a P-selectin/SELPLG ligand, it facilitates trafficking of activated T cells during inflammation and controls T cell accumulation in the inflamed central nervous system. TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is 191 a.a., with molecular weight of 35-50 kDa.

TIM-1/KIM-1/HAVCR 蛋白是一种磷脂酰丝氨酸受体，在调节 B 细胞稳态（包括其生成、扩增和抑制功能）中发挥着至关重要的作用。它作为 P-选择素/SELPLG 配体发挥作用，促进炎症反应期间活化 T 细胞的运输。该蛋白参与控制发炎的中枢神经系统 (CNS) 中 T 细胞的积累以及自身免疫性疾病的发展。它还调节多种抗炎细胞因子和共抑制配体（例如 IL10）的表达。此外，TIM-1/KIM-1/HAVCR 蛋白可作为 T 细胞增殖的调节剂，并可能在肾损伤和修复中发挥作用。它与 STAM 和 SELPLG 交互。

Mouse

HEK293

C-6*His

Q5QNS5 (Y22-T212)

171283  [NCBI]

YVEVKGVVGHPVTLPCTYSTYRGITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVESDSGLYCCRVEIPGWFNDQKVTFSLQVKPEIPTRPPTRPTTTRPTATGRPTTISTRSTHVPTSIRVSTSTPPTSTHTWTHKPEPTTFCPHETTAEVTGIPSHTPTDWNGTVT

35-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.