2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. T Cell CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins Pattern Recognition Receptors
  5. CD283/TLR3 Toll-like Receptor
  6. Toll-like Receptor 3
  7. TLR3 蛋白, Cynomolgus (681a.a, HEK293, His)

TLR3 蛋白, Cynomolgus (681a.a, HEK293, His)

目录号: HY-P700835
产品使用指南

TLR3 蛋白是 Toll 样受体家族的一部分，在先天免疫中至关重要，特别是检测病毒双链 RNA。它的识别启动信号级联，导致促炎细胞因子的产生和免疫细胞的激活。TLR3 主要在树突状细胞等免疫细胞中表达，其激活对于抗病毒防御至关重要。TLR3 信号传导失调与自身免疫和炎症性疾病有关，凸显了其潜在的治疗相关性，需要进一步研究以充分理解其免疫反应作用。TLR3 蛋白, Cynomolgus (681a.a, HEK293, His) 是重组的 TLR3 蛋白，由 HEK293 表达，带有 C-His 标签。TLR3 蛋白, Cynomolgus (681a.a, HEK293, His) 全长 681 个氨基酸，分子量为 95-115 kDa。

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描述

TLR3 Protein, part of the Toll-like receptor family, is vital in innate immunity, specifically detecting viral double-stranded RNA. Its recognition initiates a signaling cascade, leading to pro-inflammatory cytokine production and immune cell activation. Predominantly expressed in immune cells like dendritic cells, TLR3's activation is crucial for antiviral defense. Dysregulated TLR3 signaling links to autoimmune and inflammatory diseases, highlighting its potential therapeutic relevance, warranting further research to fully comprehend its immune response role. TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is the recombinant cynomolgus-derived TLR3 protein, expressed by HEK293, with C-His labeled tag. The total length of TLR3 Protein, Cynomolgus (681a.a, HEK293, His) is 681 a.a., with molecular weight of 95-115 kDa.
研究背景

TLR3 蛋白属于 Toll 样受体家族，是一组参与先天免疫反应的蛋白质。TLR3在检测病毒双链RNA方面发挥着至关重要的作用，这是许多病毒的共同特征。识别后，TLR3 会触发信号级联，导致促炎细胞因子的产生和免疫细胞的激活。这种蛋白质主要在免疫细胞中表达，例如树突状细胞和巨噬细胞，但也可以在其他细胞类型中找到。TLR3 的激活对于抗病毒防御和针对病毒感染的免疫监视至关重要。然而，TLR3 信号传导失调与多种自身免疫性疾病和炎症性疾病有关。需要进一步的研究来揭示 TLR3 在免疫反应中的全部作用及其作为治疗靶点的潜力。
种属

Cynomolgus
表达系统

HEK293
标签

C-His
蛋白编号

A0A2K5WT39 (S31-E711)
基因 ID

102138517
蛋白结构
N-term
TLR3 (S31-E711)
Accession # A0A2K5WT39
His
C-term
同用名
TLR3; CD283; IIAE2
分子量

95-115 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TLR3 Protein, Cynomolgus (681a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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