2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens
  4. TNF Superfamily Epithelial cell CD Proteins Endothelial cell CD Proteins
  5. TNF Receptor Superfamily TWEAK R/CD266
  6. TWEAK R
  7. TNFRSF12A 蛋白, Mouse (HEK293, Fc)

TNFRSF12A 蛋白, Mouse (HEK293, Fc)

目录号: HY-P72435
产品使用指南

TNFRSF12A 蛋白是 TNFSF12/TWEAK 的受体，在特定细胞中表现出微弱的凋亡诱导能力。它促进血管生成和内皮细胞增殖，并可以调节细胞对基质蛋白的粘附。在功能相互作用中，TNFRSF12A 与 TRAF1 和 TRAF2 相关，可能与 TRAF3 相关，表明它参与了促进不同细胞过程的信号通路。TNFRSF12A 蛋白, Mouse (HEK293, Fc) 是重组的 TNFRSF12A 蛋白，由 HEK293 表达，带有 C-hFc 标签。TNFRSF12A 蛋白, Mouse (HEK293, Fc) 全长 52 个氨基酸，分子量为 30-40 kDa。

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描述

TNFRSF12A Protein, a receptor for TNFSF12/TWEAK, exhibits a weak apoptosis-inducing ability in specific cells. It promotes angiogenesis and endothelial cell proliferation, and may modulate cellular adhesion to matrix proteins. In functional interactions, TNFRSF12A associates with TRAF1 and TRAF2, possibly with TRAF3, suggesting its involvement in signaling pathways contributing to diverse cellular processes. TNFRSF12A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TNFRSF12A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TNFRSF12A Protein, Mouse (HEK293, Fc) is 52 a.a., with molecular weight of 30-40 kDa.
研究背景

TNFRSF12A 蛋白作为 TNFSF12/TWEAK 的受体，在某些细胞类型中诱导细胞凋亡的能力较弱。此外，它还具有促进血管生成和刺激内皮细胞增殖的作用。TNFRSF12A 还可以调节细胞对基质蛋白的粘附。在其功能相互作用中，TNFRSF12A 与 TRAF1 和 TRAF2 相关，也可能与 TRAF3 相关，表明它参与了有助于各种细胞过程的信号传导途径。
种属

Mouse
表达系统

HEK293
标签

C-hFc
蛋白编号

Q9CR75 (E28-W79)
基因 ID

27279  [NCBI]
蛋白结构
N-term
TNFRSF12A (E28-W79)
Accession # Q9CR75
hFc
C-term
同用名
TNFRSF12A; Fibroblast growth factor-inducible immediate-early response protein 14; FN14; CD266 antigen and tweak-receptor
氨基酸序列

EQAPGTAPCSRGSSWSADLDKCMDCASCRARPHSDFCLGCAAAPPAPFRLLW

分子量

30-40 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TNFRSF12A Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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