TRPA1 蛋白, Human (HEK293, FLAG)

The TRPA1 protein functions as a receptor-activated non-selective cation channel, playing a crucial role in pain detection and potentially contributing to cold perception, oxygen concentration sensing, cough reflex, itch, and inner ear function. Demonstrating an 8-fold preference for divalent over monovalent cations, TRPA1 is involved in the pain response to endogenous inflammatory mediators and various irritants such as allylthiocyanate (AITC) from mustard oil, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein from tear gas and vehicle exhaust fumes. Additionally, TRPA1 acts as an ionotropic cannabinoid receptor, responding to delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Activation occurs through structurally unrelated electrophilic and non-electrophilic chemical compounds, with electrophilic ligands interacting covalently with critical N-terminal Cys residues. TRPA1 may also function as a component of the mechanosensitive transduction channel in inner ear hair cells, contributing to sound perception. Its activation is modulated by a cytosolic factor, possibly pyrophosphate or polyphosphates, maintaining TRPA1 in an agonist-sensitive state. Furthermore, TRPA1 is inhibited by various blockers, including ruthenium red, A-967079, AP-18, HC-030031, and the aryl sulfonamide derivative ASD, while non-covalent activation is achieved by the scorpion wasabi receptor toxin and various chemical agents.

Human

HEK293

C-Flag

O75762 (K2-P1119)

8989

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.