VTI1A 蛋白, Human (HEK293, Fc)

VTI1A Protein, a V-SNARE, mediates vesicle transport by interacting with t-SNAREs on target membranes, facilitating lipid bilayer fusion. It plays a role in vesicular transport from late endosomes to the trans-Golgi network. Collaborating with VAMP7, it participates in a non-conventional RAB1-dependent route to the cell surface used by KCNIP1 and KCND2. VTI1A interacts with SNARE complexes containing STX5 or STX6, NAPA, and to a lesser extent, NAPG. It is part of a complex with STX6, STX12, VAMP4, and VTI1A. VTI1A Protein, Human (HEK293, Fc) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-mFc labeled tag. The total length of VTI1A Protein, Human (HEK293, Fc) is 187 a.a., with molecular weight of ~48.5 kDa.

VTI1A 是一种囊泡相关的可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (V-SNARE)，通过与靶膜 t-SNARE 相互作用，在介导囊泡转运途径中发挥着至关重要的作用，有助于囊泡运输的特异性并促进脂质双层融合。该蛋白参与从晚期内体到跨高尔基体网络的囊泡运输，并与 VAMP7 一起参与 KCNIP1 和 KCND2 使用的非传统 RAB1 依赖的细胞表面运输路线。此外，VTI1A 可能与细胞衰老过程中观察到的细胞因子分泌增加有关。它与含有 STX5 或 STX6 的不同 SNARE 复合物相互作用，并与 NAPA 形成复合物，并在较小程度上与 NAPG 形成复合物。此外，VTI1A 与 STX6、STX12、VAMP4 及其本身一起存在于复合体中，突显了其在多种细胞内运输过程中的作用。

Human

HEK293

N-mFc

Q96AJ9-2 (M1-R187)

143187  [NCBI]

Approximately 48.5 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.