1. 重组蛋白
  2. Others
  3. ZNRF3 蛋白, Human (HEK293, His)

ZNRF3 蛋白, Human (HEK293, His)

目录号: HY-P78750
产品使用指南

ZNRF3作为E3泛素蛋白连接酶,在Wnt信号通路中作为负调节因子发挥着至关重要的作用。它通过介导 Wnt 受体复合物内成分(即 Frizzled 和 LRP6)的泛素化和随后的降解来实现这一点。ZNRF3 蛋白, Human (HEK293, His) 是重组的 ZNRF3 蛋白,由 HEK293 表达,带有 C-6*His 标签。ZNRF3 蛋白, Human (HEK293, His) 全长 164 个氨基酸,分子量约为 ~21 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

ZNRF3, as an E3 ubiquitin protein ligase, plays a crucial role as a negative regulator in the Wnt signaling pathway. It does this by mediating the ubiquitination and subsequent degradation of components within the Wnt receptor complex, namely Frizzled and LRP6. ZNRF3 Protein, Human (HEK293, His) is the recombinant human-derived ZNRF3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ZNRF3 Protein, Human (HEK293, His) is 164 a.a., with molecular weight of ~21 kDa.

研究背景

ZNRF3 是一种 E3 泛素蛋白连接酶,充当 Wnt 信号通路的重要负调节因子。通过介导 Wnt 受体复合物中关键成分(包括 Frizzled 和 LRP6)的泛素化和随后的降解,ZNRF3 在调节经典和非经典 Wnt 信号通路中发挥着关键作用。特别是,在肠道干细胞区,ZNRF3通过抑制Wnt信号传导发挥肿瘤抑制因子的作用,从而限制肠道干细胞区的大小。这种调节功能强调了其在控制细胞过程中的重要性。ZNRF3 与 RSPO2 和 RNF43 一起构成了控制肢体规格的主开关,强调了其在发育途径中更广泛的参与。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q9ULT6 (K56-M219)

基因 ID
蛋白结构
N-term
ZNRF3 (K56-M219)
Accession # Q9ULT6
6*His
C-term
同用名
ZNRF3; Zinc; RING finger protein 3; RING-type E3 ubiquitin transferase ZNRF3; RING finger protein 203; KIAA1133; RNF203
氨基酸序列

KETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDM

分子量

Approximately 21 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

ZNRF3 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ZNRF3 Protein, Human (HEK293, His)
目录号:
HY-P78750
需求量: