2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. SB-1436

SB-1436 是一种胆碱酯酶 Cholinesterase (ChE) 抑制剂，对乙酰胆碱酯酶 (AChE)，丁酰胆碱酯酶 (BChE) 和重组人乙酰胆碱酯酶 (rHuAChE) 具有抑制作用，IC50s 分别为 0.176，0.37 和 0.08 μM。SB-1436 以非竞争性方式抑制 AChE 和 BChE ，Kis 分别为 0.046 和 0.115 μM。SB-1436 能够显著阻止 Aβ 的自我聚集，可用于神经性疾病研究。

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SB-1436 Chemical Structure

SB-1436 Chemical Structure

CAS No. : 2925298-08-2

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SB-1436 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research[1].

IC50 & Target[1]

EeAChE

0.176 μM (IC50)

eqBCHE

0.37 μM (IC50)

EeAChE

0.046 μM (Ki)

eqBCHE

0.115 μM (Ki)

体外研究
(In Vitro)

SB-1436 (Compound 7av) (1 μM, 20 分钟) 对 AChE， BChE 和 rHuAChE 具有抑制作用，IC50s 分别为 0.176，0.37 和 0.08 μM[1]。
SB-1436 (0.78-100 μM, 48 小时) 降低了 J774A.1 细胞和初级星形胶质细胞细胞的生存能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB-1436 相关抗体:

Cell Viability Assay[1]

Cell Line: J774A.1 cells and primary astrocytes
Concentration: 0.78-100 μM
Incubation Time: 48 hours
Result: Reduced the cell viability in J774A.1 and primary astrocytes cell lines, and its GI50 in both cell types is ∼6.25 μM.
分子量

405.89

Formula

C25H21ClFNO
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-1436 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-14362925298-08-2SB1436SB 1436Cholinesterase (ChE)Cholinesterase inhibitorJ774A.1primary astrocytesAlzheimer’s diseaseADInhibitorinhibitorinhibit

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目录号：
HY-149300
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