2. PI3K/Akt/mTOR Immunology/Inflammation GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling
  3. PI3K CXCR STAT
  4. SB02024

SB02024 是一种有效的口服活性 VPS34 抑制剂。 SB02024 抑制 Vps34 激酶活性。 SB02024 通过 STAT1/IRF7 诱导 CCL5 和 CXCL10。 SB02024 显示出抗癌活性。

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SB02024 Chemical Structure

SB02024 Chemical Structure

CAS No. : 2126737-28-6

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Customer Review

SB02024 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 CXCR 亚型特异性产品:

查看所有亚型
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3].

IC50 & Target

Vps34

 

STAT1

 

体外研究
(In Vitro)

SB02024（5 μM，48 小时）在 B16-F10 和 CT26 肿瘤细胞中通过 STAT1/IRF7 诱导 CCL5 和 CXCL10[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB02024 相关抗体:

Western Blot Analysis[1]

Cell Line: B16-F10 and CT26 tumor cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Significantly up-regulates both Ccl5/Rantes and Cxcl10/IP10 mRNA and their corresponding secreted protein levels in YUMM cells, B16-F10 and CT26 tumor cells. Showed an induction of phospho-signal transducer and activator of transcription 1 (pSTAT1) and increased protein and mRNA expression of STAT1, IRF1 and IRF7.
体内研究
(In Vivo)

SB02024（20 mg/kg，口服灌胃）可减少肿瘤生长并提高抗 PD-L1/PD-1 的效果[1]。
SB02024 会增加 B16-F10 和 CT26 荷瘤小鼠血浆中 CCL5 和 CXCL10 的水平，但不会增加非荷瘤小鼠血液中 CCL5 或 CXCL10 的水平[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6, BALB/C, immunodeficient NSG mice (7 weeks old)[1]
Dosage: 20 mg/kg
Administration: Oral gavage
Result: Decreased the tumor growth and weight of B16-F10 and CT26 and prolonged the survival of tumor-bearing mice.
分子量

345.36

Formula

C16H22F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB02024 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB020242126737-28-6SB 02024SB-02024PI3KCXCRSTATPhosphoinositide 3-kinaseCXC chemokine receptorsC-X-C motif chemokine receptorsB16-F10CT26 tumor cellsYUMM cellsorally activeInhibitorinhibitorinhibit

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目录号：
HY-122891
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