2. Metabolic Enzyme/Protease
  3. Epoxide Hydrolase
  4. sEH inhibitor-16

sEH inhibitor-16 是一种可溶性环氧化物水解酶 (sEH) 抑制剂，IC50 值为 2 nM。sEH inhibitor-16 可以减少小鼠中 Cerulein (HY-A0190) 诱导的急性胰腺炎 (AP) 的炎症损伤，并可用于免疫炎症研究。

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sEH inhibitor-16 Chemical Structure

sEH inhibitor-16 Chemical Structure

CAS No. : 2999636-75-6

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sEH inhibitor-16 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research[1].

IC50 & Target

IC50: 2 nM (sEH)[1]
体内研究
(In Vivo)

sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 对 Cerulein (HY-A0190) 诱导的小鼠急性胰腺炎具有保护作用[1]。
sEH inhibitor-16 (Compound 28) (10 mg/kg，腹腔注射) 显示在 CD-1 小鼠中 T1/2 为 7.6 小时，Cmax 为 4.17 ng/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The murine model of AP induced by repeated Cerulein (HY-A0190) injections [1]
Dosage: 10mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Displayed aprotective effect evidenced bythereduction ofedema, cell infiltration, and neutrophil numbers.
Animal Model: Male CD-1 mice (Pharmacokinetic assay)[1]
Dosage: 10mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Pharmacokinetic parameters for sEH inhibitor-16 (Compound 28) in CD-1 mice[1]
Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-Ꝏ (h•ng/mL)
i.p. 10 7.6 2 4.17 29.9
分子量

455.63

Formula

C30H37N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

sEH inhibitor-16 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

sEH inhibitor-162999636-75-6sEH inhibitor16sEH inhibitor 16Epoxide HydrolaseAcute pancreatitis (AP)sEH InhibitorCerulein -Induced APinflammationInhibitorinhibitorinhibit

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