2. Cell Cycle/DNA Damage
  3. CDK
  4. Senexin A hydrochloride

Senexin A hydrochloride 是一种 CDK8/19 抑制剂 (IC50: 280 nM，CDK8)，也是 p21 转录下游的抑制剂。Senexin A hydrochloride 仅抑制 p21 诱导的转录，但不抑制 p21 的其他生物学效应。Senexin A hydrochloride 抑制 CMV-GFP 诱导，以及共有 NF-κB 依赖性启动子的 p21 刺激活性。

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Senexin A hydrochloride Chemical Structure

Senexin A hydrochloride Chemical Structure

CAS No. : 1780390-76-2

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Senexin A hydrochloride 的其他形式现货产品:

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Other Forms of Senexin A hydrochloride:

Senexin A hydrochloride 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Senexin A hydrochloride is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A hydrochloride inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters[1][2].

IC50 & Target[2]

CDK8

280 nM (IC50)

CDK8

0.83 μM (Kd)

CDK19

0.31 μM (Kd)

体外研究
(In Vitro)

Senexin A hydrochloride 抑制 CDK8 和 CDK19 ATP 位点结合，Kd50 分别为 0.83 μM 和 0.31 μM[1]。
Senexin A hydrochloride 抑制 HCT116 结肠癌细胞中 β-连环蛋白依赖性转录[1]。
在 HT1080 细胞中，Senexin A hydrochloride 强烈抑制血清饥饿时转录因子 EGR1 的诱导[1]。
Senexin A hydrochloride 还可降低阿霉素处理的野生型 HCT116 细胞中许多分泌型肿瘤促进因子的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Senexin A hydrochloride 相关抗体:
体内研究
(In Vivo)

Senexin A hydrochloride (每天 5 次) 可完全逆转化疗的肿瘤促进作用。在治疗期间，Senexin A hydrochloride 对 C57BL/6 小鼠的体重、器官重量或血细胞计数无显著毒性。Senexin A hydrochloride 可显着改善 A549/MEF 肿瘤对 Doxorubicin (HY-15142A) 的反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

310.78

Formula

C17H15ClN4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Senexin A hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Senexin A1780390-76-2CDKCyclin dependent kinasetranscription downstreamCDK8CDK19Inhibitorinhibitorinhibit

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产品名称：
Senexin A hydrochloride
目录号：
HY-15681A
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