2. Neuronal Signaling
  3. Sigma Receptor
  4. Sigma-1 receptor antagonist 4

Sigma-1 receptor antagonist 4 

目录号: HY-149274
产品使用指南

摩尔计算器

Sigma-1 receptor antagonist 4 (Compound 32) 是一种有效的 σ1R 拮抗剂，可显着增强吗啡的镇痛作用并挽救吗啡诱导的镇痛耐受性，具有预防吗啡耐受性的潜力。

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Sigma-1 receptor antagonist 4 Chemical Structure

Sigma-1 receptor antagonist 4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

Sigma-1 receptor antagonist 4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances the analgesic effect of morphine and rescues morphine-induced analgesic tolerance, with potential to prevent morphine tolerance[1].

IC50 & Target

IC50: 19.1 ± 0.6 nM (σ1R)[1]
体内研究
(In Vivo)

Sigma-1 receptor antagonist 4（0–60 mg/kg；腹腔注射；单次剂量）在 40 mg/kg 剂量范围内以剂量依赖性方式增强吗啡诱导的镇痛作用[1]。
Sigma-1 receptor antagonist 4（30 mg/kg；腹腔注射；单剂量）通过增强吗啡诱导的 MOR 激动作用来增强抗伤害作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model[1]
Dosage: 10, 20, 30, 40, 50, 60 mg/kg
Administration: i.p.; dissolved in saline with 30% PEG300 and 5% DMSO; measured the percentage of maximal possible effect (% MPE)after 30 min
Result: Dose-dependently enhanced morphine-induced analgesia within a dose of 40 mg/kg. Potentiated antinociception via enhancing the morphine-induced MOR agonism.
分子量

334.45

Formula

C22H26N2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    dissolved in saline with 30% PEG300 and 5% DMSO

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Sigma-1 receptor antagonist 4 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sigma-1 receptor antagonist 4Sigma Receptorσ1R antagonistmorphineInhibitorinhibitorinhibit

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产品名称：
Sigma-1 receptor antagonist 4
目录号：
HY-149274
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