1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl
  3. SNIPER(ABL)-039

SNIPER(ABL)-039 

目录号: HY-111874
产品使用指南

SNIPER(ABL)-039,由 Dasatinib (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 10 nM。对 ABL,cIAP1,cIAP2,XIAP 的 IC50 分别为 0.54 nM,10 nM,12 nM 和 50 nM。

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SNIPER(ABL)-039 Chemical Structure

SNIPER(ABL)-039 Chemical Structure

CAS No. : 2222354-29-0

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Description

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

IC50 & Target[1]

Abl

0.54 nM (IC50)

cIAP1

10 nM (IC50)

cIAP2

12 nM (IC50)

XIAP

50 nM (IC50)

SNIPER

 

Abl

10 nM (DC50)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1114.77

Formula

C₅₄H₆₈ClN₁₁O₉S₂

CAS No.

2222354-29-0

SMILES

CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1

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Room temperature in continental US; may vary elsewhere

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产品名称:
SNIPER(ABL)-039
目录号:
HY-111874
需求量:

SNIPER(ABL)-039

Cat. No.: HY-111874