1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl

SNIPER(ABL)-039 

目录号: HY-111874
产品使用指南

SNIPER(ABL)-039,由 Dasatinib (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 10 nM。对 ABL,cIAP1,cIAP2,XIAP 的 IC50 分别为 0.54 nM,10 nM,12 nM 和 50 nM。

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SNIPER(ABL)-039 Chemical Structure

SNIPER(ABL)-039 Chemical Structure

CAS No. : 2222354-29-0

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Description

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

IC50 & Target[1]

Abl

0.54 nM (IC50)

cIAP1

10 nM (IC50)

cIAP2

12 nM (IC50)

XIAP

50 nM (IC50)

SNIPER

 

Abl

10 nM (DC50)

References
Molecular Weight

1114.77

Formula

C₅₄H₆₈ClN₁₁O₉S₂

CAS No.

2222354-29-0

SMILES

CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
SNIPER(ABL)-039
目录号:
HY-111874
需求量:

SNIPER(ABL)-039

Cat. No.: HY-111874