1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl
  3. SNIPER(ABL)-049

SNIPER(ABL)-049 

目录号: HY-111851
产品使用指南

SNIPER(ABL)-049,由 Imatinib (ABL 抑制剂) 通过 linker 与 Bestatin (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 100 μM。

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SNIPER(ABL)-049 Chemical Structure

SNIPER(ABL)-049 Chemical Structure

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Description

SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 100 μM[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

959.14

Formula

C₅₂H₆₆N₁₀O₈

SMILES

CC1=CC=C(NC(C2=CC=C(CN3CCN(C(COCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@@H](CC4=CC=CC=C4)N)=O)=O)=O)CC3)C=C2)=O)C=C1NC5=NC=CC(C6=CC=CN=C6)=N5

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Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
SNIPER(ABL)-049
目录号:
HY-111851
需求量:

SNIPER(ABL)-049

Cat. No.: HY-111851