2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. ST247

ST247 是一种有效的 PPARβ/δ 反向激动剂。ST247 对 PPARβ/δ 具有较高的亲和力。ST247 反向调控激活标记物 CCL2 的表达。ST247 有效地诱导了与辅抑制子的相互作用。ST247 抑制激动剂诱导的 PPARβ/δ 的转录活性。

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ST247 Chemical Structure

ST247 Chemical Structure

CAS No. : 1356497-91-0

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ST247 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

查看所有亚型
PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].

IC50 & Target

PPARβ/δ

 

体外研究
(In Vitro)

ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC50 of 10 nM[1].
ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC50 of 19.1 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ST247 相关抗体:
分子量

426.55

Formula

C19H26N2O5S2
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ST247 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST2471356497-91-0ST 247ST-247PPARPeroxisome proliferator-activated receptorsWPMY-1 cellsANGPTL4CCL2inverse agonistmetabolisminflammationInhibitorinhibitorinhibit

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产品名称：
ST247
目录号：
HY-116247
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