2. Anti-infection
  3. Bacterial
  4. TAM-16

TAM-16 是一种有效的口服活性聚酮合酶 13 (Pks13) 抑制剂，IC50 值为 0.32 μM。TAM-16 对 Mycobacterium tuberculosis 具有抗结核分枝杆菌活性。TAM-16 抑制 hERG 心脏离子通道。

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TAM-16 Chemical Structure

TAM-16 Chemical Structure

CAS No. : 2030241-59-7

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TAM-16 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel[1][2].

体外研究
(In Vitro)

TAM-16 (compound 1) 抑制 M. tuberculosis 菌株 H37Rv，IC50 值为 0.08 μM[1]。
TAM-16 (0-10 μM) 通过靶向 Pks13 抑制 Mycobacterium tuberculosis[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAM-16 相关抗体:
体内研究
(In Vivo)

TAM-16 (compound 1; 200 mg/kg; p.o.; 每日一次, 持续 14 天) 可防止小鼠 TB 感染模型出现特征性肺部病变[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with tuberculosis (TB) model[2]
Dosage: 200 mg/kg
Administration: oral administration; daily, for 14 days
Result: Had a significant reduction in lung CFU counts by ∼0.9 log10 compared with the untreated control mice
分子量

380.44

Formula

C22H24N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAM-16 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAM-162030241-59-7TAM16TAM 16BacterialInhibitorinhibitorinhibit

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