2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. TAT-MEK1

TAT-MEK1 是 ERK2 的抑制剂，由 TAT 和 MEK1 (N-terminal) 组成，TAT (YGRKKRRQRRR) 源自人免疫缺陷 (HIV-1) 转录反式激活因子(TAT)，是一种穿透细胞的肽。TAT-MEK1 体外对 ERK2 的 IC50 为 29 μM。

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Custom Peptide Synthesis

TAT-MEK1 Chemical Structure

TAT-MEK1 Chemical Structure

CAS No. : 566872-16-0

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TAT-MEK1 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-MEK1 is an inhibitor ofERK2, consisting of TAT and MEK1 (N-terminal), TAT (YGRKKRRQRRR) derived from human immunodeficiency (HIV-1) transcriptional trans activator (TAT), is a cell-penetrating peptide. TAT-MEK1 IC50 in vitro for ERK2 is 29 μM[1][2].

体外研究
(In Vitro)

TAT-MEK1 (100 μM, 30 min) 在NIH.3T3和PC12细胞中能有效抑制荧光素酶的活性，对 ERK2 激活有抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-MEK1 相关抗体:

Western Blot Analysis[2]

Cell Line: NIH 3T3 and PC12
Concentration: 100 μM
Incubation Time: 30 min
Result: Inhibited luciferase activity in cells and the activity of ERK2.
分子量

3146.77

Formula

C136H241N53O31S
CAS 号
Sequence

Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Met-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro-NH2
Sequence Shortening

GYGRKKRRQRRRGMPKKKPTPIQLNP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAT-MEK1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-MEK1566872-16-0ERKExtracellular signal regulated kinasesInhibitorMAPKsMEK1inhibitorinhibit

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