2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPV3 antagonist 74a

TRPV3 antagonist 74a 是一种有效的选择性 TRPV3 拮抗剂。TRPV3 antagonist 74a 对其他离子通道面板显示无显著活性。TRPV3 antagonist 74a 可用于神经性疼痛的研究。

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TRPV3 antagonist 74a Chemical Structure

TRPV3 antagonist 74a Chemical Structure

CAS No. : 1432051-63-2

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规格 价格 是否有货
1 mg ￥2800
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5 mg ￥8400
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TRPV3 antagonist 74a 相关抗体

Top Publications Citing Use of Products

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].

IC50 & Target[1][2]

TRPV3

 

体外研究
(In Vitro)

TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TRPV3 antagonist 74a 相关抗体:
体内研究
(In Vivo)

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly[2].
. TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT mice
Dosage: 150 μg
Administration: Intradermal injection; 30 minutes
Result: The number of scratches decreased significantly.
分子量

338.32

Formula

C17H17F3N2O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

TRPV3 antagonist 74a 相关分类

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Keywords:

TRPV3 antagonist 74a1432051-63-2TRP ChannelTransient receptor potential channelspotentselectiveiondermatitisinflammationInhibitorinhibitorinhibit

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产品名称：
TRPV3 antagonist 74a
目录号：
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