2. 天然产物
  3. 疾病研究领域 植物 萜类
  4. 多孔菌科 炎症/免疫 三萜
  5. 茯苓
  6. Tumulosic acid

Tumulosic acid  (Synonyms: 土莫酸)

目录号: HY-N9366 纯度: 98.31%
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摩尔计算器

Tumulosic acid 是一种三萜类物质，可抑制 KLK5 蛋白酶活性 (IC50=14.84 μM)。Tumulosic acid 在体外抑制角质形成细胞中 LL-37 的蛋白水解过程 (≤10 μM)。

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Tumulosic acid Chemical Structure

Tumulosic acid Chemical Structure

CAS No. : 508-24-7

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1 mg ￥2100
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5 mg ￥4500
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Tumulosic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

体外研究
(In Vitro)

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes[1].
Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tumulosic acid 相关抗体:

Western Blot Analysis[1]

Cell Line: Normal human epidermal keratinocytes (NHEKs)
Concentration: 1 μM and 10 μM
Incubation Time: 23 h in the presence of 10 μM cycloheximide
Result: Decreased LL-37 production in epidermal keratinocytes.
分子量

486.73

Formula

C31H50O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

土莫酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

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  • Do most proteins show cross-species activity?

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Keywords:

Tumulosic acid508-24-7土莫酸OtherstriterpenoidKLK5proteaseproteolyticLL-37keratinocytesInhibitorinhibitorinhibit

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