2. Stem Cell/Wnt
  3. PKG
  4. Vasonatrin Peptide (VNP) (TFA)

Vasonatrin Peptide (VNP) (TFA) 

目录号: HY-P1556A 纯度: 98.79%
COA 产品使用指南

摩尔计算器

Vasonatrin Peptide (VNP) TFA 是心钠素 (ANP) 和C型利钠肽 (CNP) 的嵌合体。Vasonatrin Peptide TFA 具有 CNP 的静脉扩张作用、ANP 的利尿作用以及与 ANP 或 CNP 无关的独特的动脉血管扩张作用。Vasonatrin Peptide TFA 通过 cGMP-PKG 信号通路抑制内质网应激对糖尿病心脏缺血再灌注损伤的保护作用。

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Custom Peptide Synthesis

Vasonatrin Peptide (VNP) (TFA) Chemical Structure

Vasonatrin Peptide (VNP) (TFA) Chemical Structure

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规格 价格 是否有货 数量
500 μg ￥2000
In-stock
1 mg ￥3600
In-stock
5 mg ￥9900
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

Vasonatrin Peptide (VNP) (TFA) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vasonatrin Peptide (VNP) TFA is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). Vasonatrin peptide TFA possesses the venodilating actions of CNP, the natriuretic actions of ANP, and unique arterial vasodilating actions not associated with either ANP or CNP. Vasonatrin Peptide TFA protects the diabetic heart against ischemia-reperfusion injury by inhibiting ER stress via the cGMP-PKG signaling pathway[1][2][3].

体外研究
(In Vitro)

Vasonatrin Peptide (VNP) markedly enhances adiponectin mRNA expression, as well as protein secretion, however, suppresses IL-6 production in mature adipocytes. In addition, VNP significantly increases the intracellular levels of cGMP. The effects of VNP are mimicked by 8-br-cGMP, whereas inhibits by HS-142-1, or KT-5823[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vasonatrin Peptide (VNP) (TFA) 相关抗体:
体内研究
(In Vivo)

Vasonatrin peptide (100 μg/kg; i.v. ; 10 min before reperfusion) attenuates myocardial ischemia-reperfusion injury in diabetic rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats[3]
Dosage: 100 μg/kg
Administration: I.v. ; 10 min before reperfusion
Result: Significantly improved the instantaneous first derivation of left ventricle pressure (±LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Inhibited endoplasmic reticulum (ER) stress by suppressing glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP).
分子量

2979.39

Formula

C126H199N36O38S3F3
性状

固体

颜色

White to off-white

Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)
Sequence Shortening

GLSKGCFGLKLDRIGSMSGLGCNSFRY (Disulfide bridge: Cys6-Cys22)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Vasonatrin Peptide (VNP) (TFA) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vasonatrin Peptide (VNP) (TFA)PKGsyntheticnatriureticvasorelaxingpeptideANPCNPadipocytesdiabeticratsmyocardial ischemia-reperfusioninjuryInhibitorinhibitorinhibit

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产品名称：
Vasonatrin Peptide (VNP) (TFA)
目录号：
HY-P1556A
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