2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Veldoreotide

Veldoreotide  (Synonyms: DG3173; PTR-3173)

目录号: HY-P0024
产品使用指南

摩尔计算器

Veldoreotide (DG3173) 一种生长抑素类似物，可结合并激活生长抑素受体 (SSTR) 2/4/5。与 Octreotide (HY-P0036) 相比，Veldoreotide 在腺瘤中抑制生长激素分泌的比例更高。Veldoreotide 有被用作镇痛剂的潜力。

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Custom Peptide Synthesis

Veldoreotide Chemical Structure

Veldoreotide Chemical Structure

CAS No. : 252845-37-7

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100 mg   询价  
250 mg   询价  

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Veldoreotide 的其他形式现货产品:

Customer Review

Other Forms of Veldoreotide:

Veldoreotide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Veldoreotide (DG3173) a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1]

IC50 & Target[1]

SSTR2

37.6 nM (EC50)

SSTR3

31.3 nM (EC50)

SSTR4

10.5 nM (EC50)

体外研究
(In Vitro)

Veldoreotide 在 HEK293 细胞中以高亲和力和效率刺激 SST2、SST4 和 SST5受体，这些细胞与 GIRK2 通道共表达；GIRK2-SST2、GIRK2-SST4 和 GIRK2-SST5 的 EC50 分别为37.6 ± 4.5 nM、31.3 ± 14.4 nM和10.5 ± 3.4 nM[1]。
Veldoreotide (10 μM；24小时）抑制表达 SST4 的 BON-1 细胞[1]。
Veldoreotide (DG3173) (100 nM或1 μM；6小时) 抑制腺瘤中的GH分泌，IC50 为 0.49 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Veldoreotide 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SST4-expressing BON-1 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Inhibited SST4-expressing BON-1 cells, while did not significantly inhibited wild type BON-1 cells.
Clinical Trial
分子量

1123.30

Formula

C60H74N12O10
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Veldoreotide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veldoreotide252845-37-7DG3173 PTR-3173DG 3173DG-3173PTR3173PTR 3173PTR-3173Somatostatin ReceptorSSTRsSSTRBON-1growth hormoneGHadenomasGIRK2Inhibitorinhibitorinhibit

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目录号：
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