2. Inhibitory Antibodies
  3. XmAb 5592

XmAb 5592 

目录号: HY-P99381 纯度: 99.51%
COA

摩尔计算器

XmAb 5592 是一种人源化 Fc 工程抗 HM1.24 抗体，增强了与 FcγRIIIa 和 FcγRIIIa 受体的结合，通过抗体依赖的细胞细胞毒作用 (ADCC) 和抗体依赖的细胞吞噬作用 (ADCP) 增强 HM1.24 特异性多发性骨髓瘤 (MM) 细胞的体外裂解。

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XmAb 5592 Chemical Structure

XmAb 5592 Chemical Structure

CAS No. : 1221901-33-2

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规格 价格 是否有货 数量
1 mg ￥2800
In-stock
5 mg ￥7500
In-stock
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XmAb 5592 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XmAb 5592 is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP)[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric
体外研究
(In Vitro)

XmAb 5592 (0-1000 ng/mL) 增强对多发性骨髓瘤 (MM) 细胞的抗体依赖细胞细胞毒性 (ADCC) 和抗体依赖细胞吞噬作用 (ADCP)。与 IgG1 类似物相比，XmAb 5592 在 5-27 ng/mL 范围内显著增加所有细胞系 ADCC，还可增强巨噬细胞的抗体依赖性细胞吞噬作用 (ADCP)[1]。
XmAb 5592 (0-10000 ng/mL) 通过脱颗粒 NK 细胞诱导强烈的 MM 细胞裂解，即使存在骨髓基质细胞 (BMSCs)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

XmAb 5592 相关抗体:
体内研究
(In Vivo)

XmAb 5592 (0.3-9 mg/kg；i.p.；每周 2 次，每次 7 剂；RPMI8226 荷瘤 SCID 小鼠) 通过 FcγR 依赖机制抑制携带人 MM 异种移植物的小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with palpable RPMI8226 tumors[1]
Dosage: 0.3, 3 and 9 mg/kg
Administration: Intraperitoneal injection; twice weekly for 7 doses
Result: Inhibited growth of established myeloma tumors in vivo and eradicates tumors in mice.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XmAb 55921221901-33-2XmAb5592XmAb-5592OthersFcFcγRIIIaFcγRIIa receptorantibody-dependent cellular cytotoxicityantibody dependent cellular phagocytosismultiple myeloma cellsInhibitorinhibitorinhibit

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