2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Zanapezil fumarate

Zanapezil fumarate  (Synonyms: TAK-147 fumarate)

目录号: HY-19651B
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摩尔计算器

Zanapezil (TAK-147) fumarate 是一种有效、可逆和选择性的乙酰胆碱酯酶 (AChE) 抑制剂。Zanapezil fumarate 有效抑制大鼠大脑皮层匀浆中 AChE 活性 (IC50=51.2 nM)。Zanapezil fumarate 适度抑制毒蕈碱 M1 和 M2 受体，Ki 值分别为 234 和 340 nM。Zanapezil fumarate 可用于阿尔茨海默症早期阶段的研究。

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Zanapezil fumarate Chemical Structure

Zanapezil fumarate Chemical Structure

CAS No. : 263248-42-6

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Zanapezil fumarate 的其他形式现货产品:

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Zanapezil fumarate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD)[1][2].

IC50 & Target

AChE

 

Formula

C25H32N2O.xC4H4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Zanapezil fumarate 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zanapezil263248-42-6TAK-147TAK147TAK 147Cholinesterase (ChE)AcetylcholineesteraseAChEmuscarinicAlzheimerInhibitorinhibitorinhibit

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