2. Metabolic Enzyme/Protease
  3. FXR
  4. ZLY28

ZLY28 是一流的肠道限制性 FXR 和 FABP1 双调节剂，具有口服活性。 ZLY28 也是一种新型抗 NASH 剂。 ZLY28 可用于非酒精性脂肪性肝炎（NASH）的研究。

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ZLY28 Chemical Structure

ZLY28 Chemical Structure

CAS No. : 3004676-77-8

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ZLY28 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZLY28 is the first-in-class intestinal restricted and orally active FXR and FABP1 dual modulator. ZLY28 also is a novel anti-NASH agent. ZLY28 can be used for the research of nonalcoholic steatohepatitis (NASH)[1].
IC50 & Target

EC50: 143 nM (FXR)[1].
IC50: 2.7 μM (FABP1)[1].
体外研究
(In Vitro)

ZLY28 具有合适的肝微粒体稳定性，对 FXR（EC50 = 143 nM）和 FABP1（IC50 = 2.7 μM）具有高靶向选择性[1]< /sup>.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZLY28 相关抗体:
体内研究
(In Vivo)

ZLY28 (oral; 20 mg/kg) 通过调节 NASH 小鼠模型中的脂质代谢、炎症、氧化应激和纤维化等多种发病机制显着缓解脂肪肝[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 weeks old male C57BL/6 mice[1]
Dosage: 20 mg/kg
Administration: Oral administration
Result: Mainly distributed in the ileum with an ileum/plasma ratio of 104.1.
Significantly alleviated hepatic steatosis, lobular inflammation and ballooning.
Improved hepatic lipid homeostasis by inhibiting lipogenesis and promoting lipolysis.
Downregulated the gene expression levels.
Exhibited an acceptable safety profile with no acute toxicity.
分子量

520.40

Formula

C29H23Cl2NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZLY28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLY283004676-77-8ZLY 28ZLY-28FXRNR1H4first-in-classFABP1anti-NASHnonalcoholic steatohepatitis (NASH)Inhibitorinhibitorinhibit

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