2. Peptides
  3. γ-Fibrinogen 377-395 TFA

γ-Fibrinogen377-395 TFA 是一种纤维蛋白原衍生的抑制肽，也是纤维蛋白原表位。γ-Fibrinogen377-395 TFA 在体外可阻断小胶质细胞激活，抑制纤维蛋白与 Mac-1 的相互作用，γ-Fibrinogen377-395 TFA 在小鼠体内可抑制实验性自身免疫性脑脊髓炎 (EAE)。γ-Fibrinogen377-395 TFA 可用于研究多发性硬化症 (MS) 和其他与血脑屏障破坏和小胶质细胞激活相关的神经炎症性疾病。

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γ-Fibrinogen 377-395 TFA Chemical Structure

γ-Fibrinogen 377-395 TFA Chemical Structure

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Other Forms of γ-Fibrinogen 377-395 TFA:

γ-Fibrinogen 377-395 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1].

体外研究
(In Vitro)

γ-Fibrinogen377-395 TFA (200 μM) 阻断纤维蛋白与 Mac-1 的结合，从而抑制 Mac-1 过表达细胞与固定化纤维蛋白原的粘附。γ-Fibrinogen377-395 TFA 抑制小胶质细胞活化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Fibrinogen 377-395 TFA 相关抗体:
体内研究
(In Vivo)

γ-Fibrinogen377-395 TFA (30 μg/小鼠；鼻内给药；每天一次，持续 40 天) 增加小鼠的运动功能而不影响外周免疫反应。 γ-纤维蛋白原377-395不影响纤维蛋白原的凝血特性[1]。
在 EAE 诱导前用 γ377-395 肽免疫接种 γ377-395 肽的小鼠，与对照组相比，运动强度和协调性有所提高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)[1]
Dosage: 30 μg/mouse
Administration: Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE
Result: Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects.
分子量

2343.68

Formula

C102H166F3N25O30S2
性状

固体

颜色

White to off-white

Sequence

Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly
Sequence Shortening

YSMKETTMKIIPFNRLSIG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

纯度 & 产品资料
参考文献

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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Fibrinogen 377-395OthersInhibitorinhibitorinhibit

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