1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) 

目录号: HY-N1743
产品使用指南

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) 是从 Broussonetia kazinoki 中分离出来的,在体外对蛋白酪氨酸磷酸酶 1B (PTP1B) 具有抑制作用,IC50 为 13.00 μM。PTP1B 是胰岛素作用的负调节因子,是胰岛素抵抗和非胰岛素依赖型糖尿病发病机制中的重要介质。PTP1B 被认为是 2 型糖尿病的重要靶标。

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1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) Chemical Structure

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) Chemical Structure

CAS No. : 376362-03-7

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  • 生物活性

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生物活性

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].

分子量

326.43

Formula

C21H26O3

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl) 相关分类

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产品名称:
1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl)
目录号:
HY-N1743
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