2. Academic Validation
  3. Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki

Flavans and diphenylpropanes with PTP1B inhibition from Broussonetia kazinoki

  • Fitoterapia. 2018 Oct;130:37-42. doi: 10.1016/j.fitote.2018.08.001.
Jing-Jing Xue 1,  Chun Lei 1,  Pei-Pei Wang 2,  Kwang-Yong Kim 3,  Jing-Ya Li 2,  Jia Li 2,  Ai-Jun Hou 4
Affiliations

Affiliations

  • 1 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
  • 2 National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
  • 3 Institute of Analytical Chemistry, Han Dock Su Pyongyang University of Light Industry, Pyongyang 999093, DPR, Korea.
  • 4 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: ajhou@shmu.edu.cn.
PMID: 30086333 DOI: 10.1016/j.fitote.2018.08.001
Abstract

Three new (1a/1b and 2b) and five known flavans (2a, 6a/6b, 7, and 8), one new flavan glycoside (3), and two new (4 and 5) and six known 1,3-diphenylpropanes (9-14) were isolated from the twigs of Broussonetia kazinoki. Compounds 1, 2, and 6 are scalemic mixtures, and were resolved by chiral HPLC to provide 1a/1b, 2a/2b, and 6a/6b. The structures of these compounds were elucidated by extensive spectroscopic methods, including NMR, MS, and ECD analyses. Compounds 1, 2, 5, 8, 9, 11, and 12 showed in vitro inhibition of protein tyrosine Phosphatase 1B (PTP1B).

Keywords

1,3-Diphenylpropanes; Broussonetia kazinoki; Flavans; Moraceae; Protein tyrosine phosphatase 1B.

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