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ATWLPPR Peptide TFA 

目录号: HY-P1663A 纯度: 98.99%
产品使用指南

ATWLPPR Peptide TFA 是一种选择性的 neuropilin-1 (NRP-1) 抑制剂,能够抑制 VEGF165 与 NRP-1 结合,可用于血管生成的研究。ATWLPPR Peptide TFA 能够减轻糖尿病引起的早期视网膜损伤。

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ATWLPPR Peptide TFA Chemical Structure

ATWLPPR Peptide TFA Chemical Structure

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥26235 In-stock
1 mg ¥2500 In-stock
5 mg   Get quote  
10 mg   Get quote  

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Description

ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis[1]. ATWLPPR Peptide TFA has potential in reducing the early retinal damage caused by diabetes[2].

IC50 & Target

Neuropilin-1[2]

In Vitro

ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1 by 82% at 100 μM[1].

In Vivo

ATWLPPR (400 μg/kg, s.c.) preserves vascular integrity and decreases the oxidative stress level, possibly reduces the early retinal damage caused by diabetes[2].
ATWLPPR prevents the increase of inflammation-associated proteins (GFAP, VEGF and ICAM-1) in the retina[2].

References
Molecular Weight

954.00

Formula

C₄₂H₆₂F₃N₁₁O₁₁

SMILES

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)[C@H](C)N.OC(C(F)(F)F)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
ATWLPPR Peptide TFA
目录号:
HY-P1663A
需求量:

ATWLPPR Peptide TFA

Cat. No.: HY-P1663A