1. MAPK/ERK Pathway
  2. p38 MAPK

AZD7624 

目录号: HY-103672
产品使用指南

AZD7624 是一种可吸入的 p38 抑制剂,具有高效的抗炎活性。

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AZD7624 Chemical Structure

AZD7624 Chemical Structure

CAS No. : 1095004-78-6

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Size Stock
250 mg Get quote
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Description

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

IC50 & Target

p38[1]

In Vitro

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity. AZD7624 inhibits LPS-induced TNFα in human mononuclear cells, in whole blood as well as in alveolar macrophages in vitro, with pIC50u of 8.4, 8.7, and 9.0[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0343 mL 10.1717 mL 20.3434 mL
5 mM 0.4069 mL 2.0343 mL 4.0687 mL
10 mM 0.2034 mL 1.0172 mL 2.0343 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

491.56

Formula

C₂₇H₃₀FN₅O₃

CAS No.

1095004-78-6

SMILES

O=C(NC1CC1)C2=CC(N3C(C(NC4(C5=CC=CC=C5OCCNC)CC4)=NC=C3)=O)=C(C)C(F)=C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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产品名称:
AZD7624
目录号:
HY-103672
需求量: