1. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
  2. Proteasome
    Topoisomerase

Aclacinomycin A hydrochloride (Synonyms: Aclarubicin hydrochloride)

目录号: HY-N2306A 纯度: 98.08%
产品使用指南

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。

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Aclacinomycin A hydrochloride Chemical Structure

Aclacinomycin A hydrochloride Chemical Structure

CAS No. : 75443-99-1

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥4479 In-stock
5 mg ¥2800 In-stock
10 mg ¥4800 In-stock
25 mg ¥9800 In-stock
50 mg ¥16000 In-stock
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Description

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome[1]. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II[2]. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors[3].

IC50 & Target

20S proteasome[1].
Topoisomerase I and II[2].

References
Molecular Weight

848.33

Formula

C₄₂H₅₄ClNO₁₅

CAS No.

75443-99-1

SMILES

O=C([C@@H]1C2=CC(C(C3=CC=CC(O)=C43)=O)=C(C4=O)C(O)=C2[C@@H](O[C@@](O[C@@H](C)[C@H]5O[C@@](O[C@@H](C)[C@H]6O[C@](CCC7=O)([H])O[C@H]7C)([H])C[C@@H]6O)([H])C[C@@H]5N(C)C)C[C@]1(O)CC)OC.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
Aclacinomycin A hydrochloride
目录号:
HY-N2306A
需求量:

Aclacinomycin A hydrochloride

Cat. No.: HY-N2306A