1. Membrane Transporter/Ion Channel
  2. ATP Synthase
  3. Gboxin

Gboxin 

目录号: HY-111651 纯度: 99.32%
产品使用指南

Gboxin 是一种氧化磷酸化抑制剂,可靶向抑制胶质母细胞瘤生长。Gboxin 抑制 F0F1 ATP 合成 。具有抗肿瘤活性。

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Gboxin Chemical Structure

Gboxin Chemical Structure

CAS No. : 2101315-36-8

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥385 In-stock
5 mg ¥3500 In-stock
10 mg ¥5000 In-stock
50 mg ¥15000 In-stock
100 mg ¥21000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase[1]. Antitumour activity[1].

IC50 & Target

F0F1 ATP synthase[1]

In Vitro

Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes[1].

Cell Viability Assay[1]

Cell Line: HTS cells, MEFs and astrocytes
Concentration: 0, 185, 555, 1667, 5000, 15000 nM
Incubation Time: 96 hours
Result: Inhibited the growth of HTS cells (IC50=150 nM).
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 32.5 mg/mL (82.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5448 mL 12.7239 mL 25.4479 mL
5 mM 0.5090 mL 2.5448 mL 5.0896 mL
10 mM 0.2545 mL 1.2724 mL 2.5448 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

392.96

Formula

C₂₂H₃₃ClN₂O₂

CAS No.

2101315-36-8

SMILES

O=C(O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)CN2C(CC)=[N+](C)C3=CC=CC=C23.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Gboxin
目录号:
HY-111651
需求量:

Gboxin

Cat. No.: HY-111651