1. Cell Cycle/DNA Damage
    Epigenetics
    PI3K/Akt/mTOR
  2. HDAC
    mTOR

HDACs/mTOR Inhibitor 1 

目录号: HY-114414
产品使用指南

HDACs/mTOR Inhibitor 1 是组蛋白去乙酰酶抑制剂 (HDAC) 和哺乳动物雷帕霉素 (mTOR) 的双重抑制剂,有望用于治疗恶性血液病,其对 HDAC1、HDAC6、mTOR 和 PI3Kα 的IC50 值分别为 0.19 nM、1.8 nM、1.2 nM 和 >500 nM。HDACs/mTOR Inhibitor 1 能够引起G0/G1 期的细胞阻滞,诱导肿瘤细胞凋亡,在体内毒性较低。

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HDACs/mTOR Inhibitor 1 Chemical Structure

HDACs/mTOR Inhibitor 1 Chemical Structure

CAS No. : 2271413-06-8

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Description

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].

IC50 & Target[1]

HDAC1

0.19 nM (IC50)

HDAC6

1.8 nM (IC50)

mTOR

1.2 nM (IC50)

References
Molecular Weight

566.65

Formula

C₂₈H₃₈N₈O₅

CAS No.

2271413-06-8

SMILES

O=C(NO)CCCCCCN1C2=NC(C3=CC=C(NC(N4C[C@@H](C)OCC4)=O)C=C3)=NC(N5CCOCC5)=C2C=N1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
HDACs/mTOR Inhibitor 1
目录号:
HY-114414
需求量:

HDACs/mTOR Inhibitor 1

Cat. No.: HY-114414