Morusin (Synonyms: 桑辛素; Mulberrochromene)

目录号: HY-N0622 纯度: 99.94%: Data Sheet SDS COA 产品使用指南
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Morusin是从Morus alba Linn.分离的去乙烯基化黄酮，具有抗肿瘤，抗氧化，抗菌等各种生物活性。Morusin可抑制 NF-κB 和 STAT3 的活性。

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Morusin Chemical Structure

CAS No. : 62596-29-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥550	In-stock
5 mg	￥500	In-stock
10 mg	￥800	In-stock
25 mg	￥1500	In-stock
50 mg		询价
100 mg		询价

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Customer Review

Other Forms of Morusin:

Morusin (Standard) 询价

MCE 顾客使用本产品发表的 7 篇科研文献

•Ann Transl Med. 2020 Mar;8(6):327. [Abstract]

: Morusin purchased from MCE. Usage Cited in: Stem Cell Res Ther. 2021 Mar 12;12(1):173. [Abstract]; Stimulated mRNAs expression of Col1a1, Runx2, and Bsp is detected in BMSCs disposed with 2.5, 5, and 10 μM of Morusin for 3, 5, and 7 days, in comparison to the control group. COL1A1 and RUNX2 protein expression is found increased in osteogenic BMSCs with Morusin at days 3, 5, and 7.

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STAT3 STAT5 STAT6 STAT1

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

IC₅₀ & Target^[1]^[3]

p65

STAT3

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	24.09 μM Compound: 5	Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 27400887]
Bcap37	IC₅₀	33.1 μM Compound: 5	Cytotoxicity against human Bcap37 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human Bcap37 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 27400887]
HEK293	IC₅₀	59.4 μM Compound: 3	Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay	[PMID: 21511472]
HepG2	IC₅₀	9.3 μM Compound: 5	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 27400887]
LN-18	IC₅₀	24 μM Compound: Moursin	Cytotoxicity against human LN18 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human LN18 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26829656]
MCF7	IC₅₀	11.51 μM Compound: 5	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 27400887]
RAW264.7	IC₅₀	> 12.5 μg/mL Compound: 9	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess assay	[PMID: 27908762]
SR	IC₅₀	43.57 μM Compound: Morusin	Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay Inhibition of SERCA1 in NewZealand rabbit skeletal muscle SR vesicles using ATP as substrate incubated for 2 mins followed by Ca2+ addition by NADH coupled enzyme assay	[PMID: 32435418]
T98G	IC₅₀	24 μM Compound: Moursin	Cytotoxicity against human T98G cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human T98G cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26829656]
U138-MG	IC₅₀	24 μM Compound: Moursin	Cytotoxicity against human U138MG cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human U138MG cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26829656]
U-251	IC₅₀	17.95 μM Compound: 5	Cytotoxicity against human U251 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human U251 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay	[PMID: 27400887]
U-251	IC₅₀	24 μM Compound: Moursin	Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human U251MG cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26829656]
U-373MG ATCC	IC₅₀	24 μM Compound: Moursin	Cytotoxicity against human U373MG cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human U373MG cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26829656]
U-87MG ATCC	IC₅₀	24 μM Compound: Moursin	Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human U87MG cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 26829656]

体外研究
(In Vitro)

Morusin 对小鼠和人乳腺癌细胞表现出剂量和时间依赖性的抑制作用。对于正常乳腺上皮细胞 (MCF-10A) 的 IC₅₀ 为 9.48 μg/mL；对于小鼠乳腺癌细胞 (4T1 和 EMT6) 的 IC₅₀ 分别为 2.03 和 1.87 μg/mL；对于人乳腺癌细胞 (MCF-7 和 MDA-MB-231) 的 IC₅₀ 分别为 2.71 和 3.86 μg/mL，在 8 μg/mL 时获得最大的细胞生长抑制率 (>80％)。在 Morusin 处理的乳腺癌细胞中，凋亡细胞以剂量依赖性方式显着增加^[1]。
Morusin 显着抑制人结直肠癌 HT-29 细胞的生长和克隆形成。Morusin 还能抑制 IKK-α、IKK-β 和 IκB-β 的磷酸化，增加 IκB-α 的表达，并抑制 NF-κB 的核转位及其 DNA 结合活性。此外，还表现出 NF-κB 上游调控因子 PI3K、Akt 和 PDK1 的去磷酸化。此外，在早期时间点观察到 caspase-8 的激活、线粒体膜电位的变化、细胞色素 c 和 Smac/DIABLO 的释放以及 caspase-9 和 -3 的激活。随后 Ku70 和 XIAP 的表达下调^[2]。
Morusin 能抑制前列腺癌细胞的活力，但对正常人前列腺上皮细胞几乎没有影响。Morusin 还通过抑制 STAT3 的磷酸化、核聚集和 DNA 结合活性来降低其活性。此外，Morusin 还能下调编码 Bcl-xL、Bcl-2、Survivin、c-Myc 和 Cyclin D1 的 STAT3 靶基因的表达。它通过降低 STAT3 活性诱导人类前列腺癌细胞凋亡^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Morusin 能明显抑制乳腺癌的生长，对照组小鼠肿瘤平均重量为 1.14 g，给药 5 和 10 mg/kg Morusin 的小鼠肿瘤平均重量分别为 0.61 和 0.41 g，抑瘤率分别为 46.5% 和 64.1%^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

420.45

Formula

C₂₅H₂₄O₆

CAS 号

62596-29-6

性状

固体

颜色

Light yellow to yellow

中文名称

桑辛素；桑根白皮素

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 100 mg/mL (237.84 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3784 mL	11.8920 mL	23.7840 mL
5 mM	0.4757 mL	2.3784 mL	4.7568 mL
10 mM	0.2378 mL	1.1892 mL	2.3784 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.95 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。
生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.95 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 MCE 网站选购。，Tween 80，均可在 MCE 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.94%

选择批次：

Data Sheet (655 KB) SDS (393 KB)

COA (292 KB) HNMR (279 KB) LCMS (263 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Li H, et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015 Nov 4;34:137. [Content Brief]

[2]. Lee JC, et al. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42. [Content Brief]

[3]. Lim SL, et al. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res. 2014 Dec 15;5(1):289-99. [Content Brief]

Cell Assay ^[1]	The cytotoxicity of morusin against human normal mammary epithelial cells and murine breast cancer cells (4 T1 and EMT6) and human breast cancer cells (MCF-7 and MDA-MB-231) is tested by modified MTT assay [23]. Cells are treated with various concentrations of morusin (1, 2, 4, 6 and 8 μg/mL). After treatment with morusin for 1, 2, 3, 4, and 5 days, 20 μL MTT (pH 4.7) is added to each well, and cultivated for another 4 h, 100 μL of 10 % SDS/0.01 N HCl is added and incubated at 37 °C overnight to dissolve the formazan. Absorbance is measured at 570 nm^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[1]	Mice: Two treatment group mice are injected with 5 and 10 mg/kg of morusin i.p. three times weekly for 4 weeks, respectively, and the control mice are injected with DMSO. During the experiment, mice are weighted, and tumor volumes are measured weekly using calipers and their volumes are calculated^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Li H, et al. Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. J Exp Clin Cancer Res. 2015 Nov 4;34:137. [Content Brief] [2]. Lee JC, et al. Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun. 2008 Jul 18;372(1):236-42. [Content Brief] [3]. Lim SL, et al. Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. Am J Cancer Res. 2014 Dec 15;5(1):289-99. [Content Brief]

Morusin 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3784 mL	11.8920 mL	23.7840 mL	59.4601 mL
	5 mM	0.4757 mL	2.3784 mL	4.7568 mL	11.8920 mL
	10 mM	0.2378 mL	1.1892 mL	2.3784 mL	5.9460 mL
	15 mM	0.1586 mL	0.7928 mL	1.5856 mL	3.9640 mL
	20 mM	0.1189 mL	0.5946 mL	1.1892 mL	2.9730 mL
	25 mM	0.0951 mL	0.4757 mL	0.9514 mL	2.3784 mL
	30 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9820 mL
	40 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.4865 mL
	50 mM	0.0476 mL	0.2378 mL	0.4757 mL	1.1892 mL
	60 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL
	80 mM	0.0297 mL	0.1487 mL	0.2973 mL	0.7433 mL
	100 mM	0.0238 mL	0.1189 mL	0.2378 mL	0.5946 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Morusin62596-29-6Mulberrochromene桑辛素桑根白皮素NF-κBSTATBacterialNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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Morusin (Synonyms: 桑辛素; Mulberrochromene)

Customer Review

Other Forms of Morusin:

MCE 顾客使用本产品发表的 7 篇科研文献

Morusin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 NF-κB 亚型特异性产品:

查看 STAT 亚型特异性产品:

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实验参考方法

纯度 & 产品资料

参考文献

摩尔计算器

稀释计算器

Morusin 相关分类

完整储备液配制表

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Morusin (Synonyms: 桑辛素; Mulberrochromene)

Customer Review

Other Forms of Morusin:

Morusin 相关抗体

MCE 顾客使用本产品发表的 7 篇科研文献

Morusin 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

查看 NF-κB 亚型特异性产品:

查看 STAT 亚型特异性产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Morusin 相关抗体:

摩尔计算器

稀释计算器

Morusin 相关分类

完整储备液配制表

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