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Ogerin 

目录号: HY-110279 纯度: 99.60%
产品使用指南

Ogerin 是一种选择性的 GPR68 正向别构调节剂,pEC50 值为 6.83。Ogerin 对 A2A 受体具有适中的拮抗作用,Ki 值为 220 nM;对 5-HT2B 受体的拮抗作用较弱,Ki 值为 736 nM。Ogerin 抑制小鼠对恐惧记忆的回忆。

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Ogerin Chemical Structure

Ogerin Chemical Structure

CAS No. : 1309198-71-7

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Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥88 In-stock
5 mg ¥900 In-stock
10 mg ¥1600 In-stock
25 mg ¥3300 In-stock
50 mg ¥5600 In-stock
100 mg ¥9500 In-stock
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Description

Ogerin is a selective GPR68 positive allosteric modulator, with a pEC50 of 6.83. Ogerin shows inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptoor and weak antagonist activity (Ki, 736 nM) at 5-HT2B receptor. Ogerin blocks recall in fear conditioning in mice[1].

IC50 & Target

pEC50: 6.83 (GPR68)[1]
Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor)[1]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (813.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2536 mL 16.2681 mL 32.5362 mL
5 mM 0.6507 mL 3.2536 mL 6.5072 mL
10 mM 0.3254 mL 1.6268 mL 3.2536 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.77 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.77 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.77 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

307.35

Formula

C₁₇H₁₇N₅O

CAS No.

1309198-71-7

SMILES

OCC1=C(C2=NC(N)=NC(NCC3=CC=CC=C3)=N2)C=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
Ogerin
目录号:
HY-110279
需求量:

Ogerin

Cat. No.: HY-110279