2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor VEGFR
  4. R916562

R916562 是口服有效的，选择性的 Axl/VEGF-R2 双抑制剂，IC50 分别为 136 nM 和 24 nM。R916562 具有抗血管生成和抗癌转移作用。

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R916562 Chemical Structure

R916562 Chemical Structure

CAS No. : 1037798-41-6

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R916562 相关抗体

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis[1].

IC50 & Target

VEGF-R2

24 nM (IC50)

Axl

136 nM (IC50)

体内研究
(In Vivo)

R916562 treatment at 85 mg/kg or 125 mg/kg orally b.i. d for 21 days results in statistically significant tumor growth inhibitions of 69% or 83% respectively. R916562 shows 73% reduction in fibroblast growth factor-induced neovascularization in a mouse corneal micropocket assay at a dose of 100 mg/kg and 50% reduction at 50 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

536.09

Formula

C26H30ClN9S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]

The nu/nu mice are used in the study. In the MDA-MB-231 human breast cancer xenograft model, mice are given 125 mg/kg b.i.d. orally for 21 days. Mean tumor volume is measured[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

R916562 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R9165621037798-41-6R 916562R-916562TAM ReceptorVEGFRTyro3AxlMerVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-104075
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