2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Rivastigmine tartrate

Rivastigmine tartrate  (Synonyms: 酒石酸卡巴拉汀; ENA 713; SDZ-ENA 713)

目录号: HY-11017 纯度: 99.71%
COA 产品使用指南

摩尔计算器

Rivastigmine tartrate (ENA 713; SDZ-ENA 713) 是一种具有口服活性的，有效的胆碱酯酶 (ChE) 抑制剂，可抑制丁酰胆碱酯酶 (BChE) 和乙酰胆碱酯酶 (AChE)，IC50 分别为 0.037 μM 和 4.15 μM。Rivastigmine tartrate 可透过血脑屏障 (BBB)。Rivastigmine tartrate 是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Rivastigmine tartrate Chemical Structure

Rivastigmine tartrate Chemical Structure

CAS No. : 129101-54-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥660
In-stock
50 mg ￥600
In-stock
100 mg ￥900
In-stock
200 mg ￥1200
In-stock
500 mg   询价  
1 g   询价  

* Please select Quantity before adding items.

Other Forms of Rivastigmine tartrate:

Rivastigmine tartrate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].

IC50 & Target

IC50: 0.037 μM (BChE) and 4.15 μM (AChE)[1]
体外研究
(In Vitro)

Rivastigmine tartrate (ENA 713; 1 µM; 24 hours) reduces LPS (2.5 µg/ml)-induced TNF-α and IL-6 by 50% and 46% combined with carbachol (10 µM), respectively and does not cause any significant reduction in pro-inflammatory cytokines [3].
Rivastigmine tartrate (1 µM), carbachol (10 µM), or a combination of both drugs, does not have a cytotoxic effect on activated cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rivastigmine tartrate 相关抗体:
体内研究
(In Vivo)

Rivastigmine tartrate (ENA 713; 0.5-2.5 mg/kg; IP; 60 min before the tests) significantly and dose-dependently improved the behavioral impairments caused by Aluminum (HY-B1521)[4].
Rivastigmine (0.5, 1 mg/kg/day; s.c; for 8 days) reduces by about 50% and 60% respectively, the concentration of IL-6 but not those of TNF-α and IL-1β in BALB/c OlaHsd male mice aged 8-9 weeks weighing 200–250 g with acute colitis[3].
Rivastigmine (1 mg/kg), but not (0.5 mg/kg), partially antagonized colon shrinkage and completely prevented bleeding. Treatment with rivastigmine (0.5 mg/kg) causes little change in these pathological manifestations, but rivastigmine (1 mg/kg) causes a partial restoration of the structure of the crypts and a reduction in sub-mucosal edema and cell infiltration. Rivastigmine (1 mg/kg) causes a 4.7% reduction in body weight at the end of the experiment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar albino rats weighing 190–240 g (90 days old)[4]
Dosage: 0.5, 1, 1.5 and 2.5 mg/kg
Administration: IP; single dose
Result: Significantly and dose-dependently improved the behavioral impairments caused by Aluminum (100 mg/kg/day; i.p.; for 60 days)
Clinical Trial
分子量

400.42

Formula

C18H28N2O8
CAS 号
性状

固体

颜色

White to off-white

中文名称

酒石酸卡巴拉汀；利斯的明酒石酸盐；卡巴拉汀酒石酸盐；酒石酸利伐斯的明；酒石酸利凡斯的明
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (124.87 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4974 mL 12.4869 mL 24.9738 mL
5 mM 0.4995 mL 2.4974 mL 4.9948 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (249.74 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Rivastigmine tartrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4974 mL 12.4869 mL 24.9738 mL 62.4344 mL
5 mM 0.4995 mL 2.4974 mL 4.9948 mL 12.4869 mL
10 mM 0.2497 mL 1.2487 mL 2.4974 mL 6.2434 mL
15 mM 0.1665 mL 0.8325 mL 1.6649 mL 4.1623 mL
20 mM 0.1249 mL 0.6243 mL 1.2487 mL 3.1217 mL
25 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4974 mL
30 mM 0.0832 mL 0.4162 mL 0.8325 mL 2.0811 mL
40 mM 0.0624 mL 0.3122 mL 0.6243 mL 1.5609 mL
50 mM 0.0499 mL 0.2497 mL 0.4995 mL 1.2487 mL
60 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0406 mL
80 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7804 mL
100 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rivastigmine129101-54-8ENA 713 SDZ-ENA 713酒石酸卡巴拉汀利斯的明酒石酸盐卡巴拉汀酒石酸盐酒石酸利伐斯的明酒石酸利凡斯的明ENA713ENA-713Cholinesterase (ChE)orallycholinesteraseChEbutyrylcholinesteraseBChEacetylcholinesterasparasympathomimeticcholinergicAlzheimer'sParkinson'sdiseaseBBBInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Rivastigmine tartrate
目录号：
HY-11017
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z