1. Cell Cycle/DNA Damage
  2. Aurora Kinase

Aurora Kinase

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39 to 129 residues in length, a protein kinase domain and a short C-terminal domain containing 15 to 20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein-protein interactions.

Aurora Kinase 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-10971
    Alisertib Inhibitor 98.96%
    Alisertib 是一种具有选择性的 Aurora A 抑制剂,IC50 值为 1.2 nM,对 Aurora A 的选择性高于 Aurora B。
  • HY-10161
    Tozasertib Inhibitor 99.79%
    Tozasertib 是一种 Aurora-A,Aurora-B,Aurora-C 抑制剂,Ki 值为 0.6,18,4.6 nM。
  • HY-10179
    Danusertib Inhibitor 99.44%
    Danusertib 是一种激光激酶 (aurora kinase) 抑制剂,能够抑制 Aurora A,Aurora B 和 Aurora C 的活性,IC50 值分别为 13,79 和 61 nM。
  • HY-13253
    AMG 900 Inhibitor 99.30%
    AMG 900 是一种有效的选择性的 pan-Aurora 激酶抑制剂,作用于 Aurora ABCIC50 分别为 5 nM,4 nM 和 1 nM。
  • HY-13252
    MK-5108 Inhibitor >98.0%
    MK-5108是高效和特异性的Aurora-A激酶抑制剂,IC50值为0.064 nM。
  • HY-10180
    MLN8054 Inhibitor 98.25%
    MLN8054是Aurora A 选择性抑制剂,IC50为4 nM。
  • HY-12054
    Hesperadin Inhibitor 99.67%
    Hesperadin是ATP竞争性Aurora B抑制剂,IC50为250 nM。
  • HY-10126
    AZD1152-HQPA Inhibitor 99.59%
    AZD1152-HQPA 是一种高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM,对 Aurora B 的选择性是 Aurora A 的 3700 倍。
  • HY-50514
    AT9283 Inhibitor 99.13%
    AT9283 是一种多靶点抑制剂,抑制 JAK2JAK3 的活性,IC50 值分别为 1.2 nM 和 1.1 nM;对 Aurora A,Aurora B 和 Abl(T315I) 也有作用。
  • HY-10128
    ZM-447439 Inhibitor 98.88%
    ZM 447439是ATP竞争性Aurora A和B选择性抑制剂,IC50分别为110 nM和130 nM。
  • HY-10127
    AZD1152 Inhibitor
    AZD1152 是 barasertib-hQPA 的前体药物,是高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM。
  • HY-14711
    Reversine Inhibitor 98.16%
    Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂,作用于 Aurora AAurora BAurora CIC50 分别为 400,500 和 400 nM。
  • HY-12201
    TAK-901 Inhibitor 99.80%
    TAK-901是新型的Aurora A和B抑制剂,IC50分别为21 nM和15 nM。
  • HY-70044
    GSK-1070916 Inhibitor 99.55%
    GSK1070916是可逆的ATP竞争性Aurora B和C抑制剂,IC50分别为3.5 nM和6.5 nM。而对于Aurora A-TPX2复合物的IC50则为490 nM。
  • HY-10329
    JNJ-7706621 Inhibitor 99.82%
    JNJ-7706621是CDK抑制剂,对CDK1/2的抑制性最强,对应的IC50分别为9 nM/4 nM,比对CDK3/4/6的抑制性强超过6倍,对Aurora A/B有抑制性,而对Plk1和Wee1无活性。
  • HY-14574
    PF-03814735 Inhibitor 99.24%
    PF-03814735是口服生物相容性的可逆的Aurora抑制剂,对Aurora A,Aurora B,Flt 1和FAk的IC50分别为0.8,5,10和22 nM。
  • HY-15767
    TAK-632 Inhibitor 98.87%
    TAK-632 是一种有效的 pan-RAF 抑制剂,作用于 CRAFBRAFV600EBRAFWTIC50 分别为 1.4,2.4 和 8.3 nM。
  • HY-10804
    CCT 137690 Inhibitor 98.33%
    CCT 137690是Aurora抑制剂,对Aurora A,Aurora C和Aurora B的IC50分别为15,19和25 nM。
  • HY-70061
    Aurora A inhibitor I Inhibitor 99.63%
    Aurora A抑制剂I是Aurora A选择性抑制剂,对Aurora A和Aurora B的IC50分别为3.4nM和3.4 μM。
  • HY-12003
    SNS-314 Inhibitor 99.81%
    SNS-314是Aurora A,Aurora B和Aurora C抑制剂,IC50分别为9 nM,31 nM和3 nM。