1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

Aurora Kinase

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39 to 129 residues in length, a protein kinase domain and a short C-terminal domain containing 15 to 20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein-protein interactions.

Aurora Kinase 相关产品 (32):

Cat. No. Product Name Effect Purity
  • HY-10971
    Alisertib Inhibitor 99.43%
    Alisertib 是一种具有选择性的 Aurora A 抑制剂,IC50 值为 1.2 nM,对 Aurora A 的选择性高于 Aurora B。
  • HY-10161
    Tozasertib Inhibitor 99.77%
    Tozasertib 是一种 Aurora-A,Aurora-B,Aurora-C 抑制剂,Ki 值为 0.6,18,4.6 nM。
  • HY-50514
    AT9283 Inhibitor 99.13%
    AT9283 是一种多靶点抑制剂,抑制 JAK2JAK3 的活性,IC50 值分别为 1.2 nM 和 1.1 nM;对 Aurora A,Aurora B 和 Abl(T315I) 也有作用。
  • HY-10180
    MLN8054 Inhibitor >98.0%
    MLN8054是高效,选择性,有口服活性的极光激酶 (aurora A) 抑制剂,IC50 值为4 nM。
  • HY-10126
    AZD1152-HQPA Inhibitor 99.64%
    AZD1152-HQPA 是一种高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM,对 Aurora B 的选择性是 Aurora A 的 3700 倍。
  • HY-10179
    Danusertib Inhibitor 99.44%
    Danusertib 是一种激光激酶 (aurora kinase) 抑制剂,能够抑制 Aurora A,Aurora B 和 Aurora C 的活性,IC50 值分别为 13,79 和 61 nM。
  • HY-14711
    Reversine Inhibitor 99.25%
    Reversine 是一种ATP-竞争性的 Aurora kinase 抑制剂,作用于 Aurora AAurora BAurora CIC50 分别为 400,500 和 400 nM。
  • HY-13252
    MK-5108 Inhibitor 98.62%
    MK-5108是高效和特异性的Aurora-A激酶抑制剂,IC50值为0.064 nM。
  • HY-12054
    Hesperadin Inhibitor 98.48%
    Hesperadin是ATP竞争型的极光激酶 (aurora B) 抑制剂,IC50值为250 nM。
  • HY-10127
    AZD1152 Inhibitor
    AZD1152 是 Barasertib-hQPA 的前体药物,是高度选择性的 Aurora B 抑制剂,IC50 值为 0.37 nM。
  • HY-13253
    AMG 900 Inhibitor 98.19%
    AMG 900 是一种有效的选择性的 pan-Aurora 激酶抑制剂,作用于 Aurora ABCIC50 分别为 5 nM,4 nM 和 1 nM。
  • HY-12201
    TAK-901 Inhibitor 99.80%
    TAK-901是多靶点的的极光激酶 (aurora)抑制剂,对极光激酶A和B的IC50 值分别为21 和15 nM。
  • HY-70044
    GSK-1070916 Inhibitor 99.55%
    GSK-1070916是有效,选择性,ATP竞争型的极光激酶B/C (aurora B/C) 抑制剂,Ki 值分别为0.38和1.5 nM。
  • HY-10339
    KW-2449 Inhibitor 99.85%
    KW-2449是多靶点激酶抑制剂,对FLT3ABLABLT315IAurora kinaseIC50 值分别为6.6,14,4 和 48 nM.
  • HY-10128
    ZM-447439 Inhibitor 98.59%
    ZM-447439是极光激酶 (aurora) 抑制剂,对aurora A和B的 IC50 值分别为110和130 nM。
  • HY-10329
    JNJ-7706621 Inhibitor 98.80%
    JNJ-7706621 是一种有效的 aurora kinase 抑制剂,同时能有效抑制 CDK1CDK2,对 CDK1,CDK2,Aurora-A 和 Aurora-B 的 IC50 值分别为 9,3,11 和 15 nM。
  • HY-14574
    PF-03814735 Inhibitor 99.77%
    PF-03814735是有效,有口服性,可逆的极光激酶A和B (aurora A/B) 的抑制剂,IC50值分别为0.8和5 nM。
  • HY-15749
    XL228 Inhibitor 99.58%
    XL228是多靶点的酪氨酸激酶抑制剂,对Bcr-AblAurora AIGF-1RSrcLynIC50 值分别为5,3.1,1.6,6.1,2 nM。
  • HY-15767
    TAK-632 Inhibitor 98.87%
    TAK-632 是一种有效的 pan-RAF 抑制剂,作用于 CRAFBRAFV600EBRAFWTIC50 分别为 1.4,2.4 和 8.3 nM。
  • HY-10987A
    ENMD-2076 Inhibitor 98.77%
    ENMD-2076是多靶点激酶抑制剂,抑制 Aurora AFlt3KDR/VEGFR2Flt4/VEGFR3FGFR1FGFR2SrcPDGFRαIC50 值分别为1.86,14,58.2,15.9,92.7,70.8,20.2 and 56.4 nM。