1. Neuronal Signaling
  2. Dopamine Transporter

Dopamine Transporter

Dopamine Transporter (DAT) is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. Dopamine transporter (DAT) controls the spatial and temporal dynamics of dopamine (DA) neurotransmission by driving reuptake of extracellular transmitter into presynaptic neurons. Many diseases such as depression, bipolar disorder, Parkinson’s disease, and attention deficit hyperactivity disorder are associated with abnormal DA levels, implicating DAT as a factor in their etiology. Medications used to treat these disorders and many addictive drugs target DAT and enhance dopaminergic signaling by suppressing transmitter reuptake. DAT is regulated by multiple signaling systems, with PKC and ERK being two of the most well-characterized.

Dopamine Transporter 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-13217
    Vanoxerine dihydrochloride Inhibitor 99.64%
    Vanoxerine (GBR12909)双盐酸盐是多巴胺重吸收抑制剂(DRI)。
  • HY-B1272
    Desipramine hydrochloride Inhibitor 99.68%
    Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET), 5-羟色胺转运体 (SERT) 和多巴胺转运 (DAT) 的抑制剂,其 Ki 值分别为 4, 61 和 78,720 nM。
  • HY-B0403A
    Bupropion hydrochloride Inhibitor 99.06%
  • HY-B1124
    Fipexide Inhibitor 99.87%
    Fipexide是一种哌嗪类的抗精神药物, 用作一种健脑药, 主要用于治疗老年痴呆。
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺,去甲肾上腺素和三羟色胺转运蛋白的三重再摄取抑制剂,IC50值分别为4,6和11 nM。
  • HY-12242
    GBR 12935 dihydrochloride Inhibitor 98.90%
    GBR 12935双盐酸盐是多巴胺再吸收抑制剂。
  • HY-13217A
    Vanoxerine Inhibitor
    Vanoxerine (GBR12909)是多巴胺重吸收抑制剂(DRI)。
  • HY-18610
    Diclofensine hydrochloride Inhibitor
  • HY-18610A
    Diclofensine Inhibitor
  • HY-101631
    Levophacetoperane hydrochloride Inhibitor
    Levophacetoperane竞争性抑制去甲肾上腺素 (norepinephrin) 摄取和多巴胺 (dopamine) 摄取。
  • HY-101612
    SPD-473 citrate Inhibitor
    SPD-473 citrate 是 5-HT/多巴胺/去甲肾上腺素再摄取抑制剂。
  • HY-12242A
    GBR 12935 Inhibitor
    GBR 12935是多巴胺再吸收抑制剂。
  • HY-U00306
    Cocaethylene Inhibitor
    Cocaethylene 是 cocaine 的有效代谢物,为有效的 dopamine transporter 抑制剂,抑制 [3H]Mazindol 与 dopamine transporter 结合,Ki 值为 0.6 μM。
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