1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

E1/E2/E3 Enzyme 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-13296
    PYR-41 Inhibitor >98.0%
    PYR-41 是一种特异的,细胞可透过的 E1 抑制剂,IC50 值 < 10 μM。
  • HY-100507
    CC122 Agonist 99.37%
    CC122是一种新型的治疗DLBCL的药物,具有抗肿瘤和调节免疫活动的作用。CC122可以结合CRBN,通过降解Aiolos和Ikaros可以模仿干扰素信号,引发DLBCL的细胞凋亡。
  • HY-15301
    CC0651 Inhibitor 99.30%
    CC0651 是一种人Cdc34泛素结合酶变构抑制剂。CC0651 有效抑制 p27Kip1的泛素化,IC50 为 1.72 μM。
  • HY-19817
    PRT4165 Inhibitor >98.0%
    PRT4165是有效的PRC1(Polycomb-repressive complex 1)介导的H2A泛素化抑制剂。
  • HY-18643
    TZ9 Inhibitor
    TZ9是泛素结合酶(E2 enzyme)Rad6新型抑制剂,抑制MDA-MB-231细胞增殖的IC50值约为6uM。
  • HY-101836
    DKM 2-93 Inhibitor 98.87%
    DKM 2-93是相对选择性的UBA5抑制剂,IC50值为430 μM。
  • HY-103236
    NSC232003 Inhibitor 98.09%
    NSC232003 是一种高效的可渗透细胞的 UHRF1 抑制剂,可抑制 DNA 甲基化,并破坏 DNMT1/UHRF1 相互作用。
  • HY-13297
    PYZD-4409 Inhibitor 98.51%
    PYZD-4409是泛素激活酶E1抑制剂,IC50为20 uM。