1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme

E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

E1/E2/E3 Enzyme 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-N0077
    Ginkgolic Acid Inhibitor 99.59%
    Ginkgolic Acid 是一种天然化合物,能够引起体内/体外蛋白类泛素化,但不影响体内泛素化。
  • HY-13296
    PYR-41 Inhibitor >98.0%
    PYR-41 是一种特异的,细胞可透过的 E1 抑制剂,IC50 值 < 10 μM。
  • HY-100237
    SZL P1-41 Inhibitor 99.53%
    SZL P1-41是Skp2抑制剂,有选择性的抑制Skp2 E3连接酶的活性,对于其它的SCF复合物没有活性。
  • HY-100507
    CC122 Agonist 99.37%
    CC122是一种新型的治疗DLBCL的药物,具有抗肿瘤和调节免疫活动的作用。CC122可以结合CRBN,通过降解Aiolos和Ikaros可以模仿干扰素信号,引发DLBCL的细胞凋亡。
  • HY-103236
    NSC232003 Inhibitor 98.09%
    NSC232003 是一种高效的可渗透细胞的 UHRF1 抑制剂,可抑制 DNA 甲基化,并破坏 DNMT1/UHRF1 相互作用。
  • HY-19817
    PRT4165 Inhibitor >98.0%
    PRT4165 是一种有效的 PRC1 介导的 H2A 泛素化的抑制剂。
  • HY-18643
    TZ9 Inhibitor 99.17%
    TZ9是泛素结合酶(E2 enzyme)Rad6新型抑制剂,抑制MDA-MB-231细胞增殖的IC50值约为6uM。
  • HY-101836
    DKM 2-93 Inhibitor 98.87%
    DKM 2-93是相对选择性的UBA5抑制剂,IC50值为430 μM。
  • HY-16661
    Skp2 Inhibitor C1 Inhibitor 98.80%
    Skp2 Inhibitor C1(SKPin C1)是特异的Skp2介导的p27降解抑制剂。
  • HY-15301
    CC0651 Inhibitor 99.30%
    CC0651 是一种人Cdc34泛素结合酶变构抑制剂。CC0651 有效抑制 p27Kip1的泛素化,IC50 为 1.72 μM。
  • HY-13297
    PYZD-4409 Inhibitor >98.0%
    PYZD-4409是泛素激活酶E1抑制剂,IC50为20 uM。