1. Immunology/Inflammation
  2. FLAP


FLAP (Arachidonate 5-lipoxygenase-activating protein) is a protein that in humans is encoded by the ALOX5AP gene. FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes. It is an integral protein within the nuclear membrane. FLAP is necessary in synthesis of leukotriene, which are lipid mediators of inflammation that is involved in respiratory and cardiovascular diseases. FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease. Leukotrienes, which need the FLAP protein to be made, have an established pathological role in allergic and respiratory diseases. Animal and human genetic evidence suggests they may also have an important role in atherosclerosis, myocardial infarction, and stroke. The structure of FLAP provides a tool for the development of novel therapies for respiratory and cardiovascular diseases and for the design of focused experiments to probe the cell biology of FLAP and its role in leukotriene biosynthesis.

FLAP 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-14166
    MK-886 Inhibitor 99.70%
    MK886是<5>脂氧合酶活化蛋白抑制剂和白三烯生物合成抑制剂 (IC50=2.5 nM)。
  • HY-15874
    GSK2190915 Inhibitor 98.18%
    GSK2190915(AM-803; Fiboflapon)是FLAP高效选择性抑制剂,binding IC50值为2.9nM。
  • HY-50714
    MK591 Inhibitor 99.25%
    MK591 是选择性的,特异性的 FLAP 抑制剂。
  • HY-15874A
    GSK2190915 sodium salt Inhibitor 99.08%
    GSK2190915钠盐(AM-803; Fiboflapon)是FLAP高效选择性抑制剂,binding IC50值为2.9nM。
  • HY-14460
    AM679 Inhibitor 99.98%
    AM679是高活性FLAP抑制剂,对FLAP结合/hLA/hWB的IC50分别为2.2 nM/0.6 nM/154 nM。
  • HY-10037
    MK591 free acid Inhibitor
    MK591 (free acid) 是FLAP特异性抑制剂,IC50 为1.6 nM。
  • HY-14163
    AM 103 Inhibitor
    AM 103 是具有选择性的,有效的 FLAP 抑制剂,IC50 值为 4.2 nM。
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