1. Signaling Pathways
  2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)

NOD-like Receptor (NLR)

Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-κB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. NLRs including Nod1 and Nod2 are thought to be kept in an inactive state by intra-molecular interactions.

The central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses. NLRs are classified as part of the signal transduction ATPases with numerous domains (STAND) clade within the AAA+ ATPase family.

NOD-like Receptor (NLR) 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-12815A
    MCC950 sodium Inhibitor 99.43%
    MCC950 sodium是一种有效,选择性的 NLRP3 抑制剂,在BMDMs 和 HMDMs中的 IC50 分别为 7.5 nM 和 8.1 nM。
  • HY-12815
    MCC950 Inhibitor >98.0%
    MCC950 是一种有效,选择性的 NLRP3 抑制剂,在BMDMs 和 HMDMs中的IC50 分别为 7.5 nM 和 8.1 nM。
  • HY-103666
    CY-09 Inhibitor >98.0%
    CY-09 是 NLRP3 的抑制剂。
  • HY-100691
    NOD-IN-1 Inhibitor 98.99%
    NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂,IC50 值分别为 5.74 μM 和 6.45 μM。
  • HY-101868
    INF39 Inhibitor 99.61%
    INF39 是不可逆的,没有细胞毒性的NLRP3 抑制剂。
  • HY-17629
    Dapansutrile Inhibitor >98.0%
    Dapansutrile (OLT1177)是有效,选择性和有口服活性的 NLRP3 炎性小体抑制剂。 具有抗炎,镇痛活性。
  • HY-111815
    N4-Acetylcytidine triphosphate Activator
    N4-Acetylcytidine triphosphate 是一种内源性核苷代谢物,源于 tRNA 的降解,可通过诱导 HMGB1 的表达,启动和激活 NLRP3 炎症。
  • HY-N0496
    Ruscogenin Inhibitor
    Ruscogenin 是从麦冬的提取的一种重要甾体皂苷元,通过抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径,减轻脑缺血诱导的血脑屏障功能障碍,具有显著的抗炎和抗血栓活性。
  • HY-N0139
    Troxerutin Inhibitor 98.05%
    Troxerutin 也被称为维生素 P4,是天然生物类黄酮芦丁的三羟乙基化衍生物,其可抑制活性氧 (ROS) 的产生并抑制 ER 应激介导的 NOD 活化。
  • HY-18639
    Nodinitib-1 Inhibitor >98.0%
    Nodinitib-1 (ML130;CID-1088438)是NOD1抑制剂,IC50值为0.56 μM。
  • HY-16059
    Arglabin Inhibitor 99.17%
    Arglabin由亮绿蒿中提取获得的天然产物,具有抗癌活性。
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