1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel 相关产品 (88):

Cat. No. Product Name Effect Purity
  • HY-100381
    Nigericin sodium salt Activator >98.0%
    Nigericin sodium salt 是从吸水链霉菌中得到的一种抗生素,作为 H+,K+ 和 Pb2+ 离子载体起作用。
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride 是一种有效的 dopamine D2 受体,5-HT2A 受体,potassium channelsodium channel 的拮抗剂,抑制 D2 受体和 serotonin 5-HT2A 受体的活性,Ki 值分别为 363 nM 和 8.3 nM。
  • HY-50694
    Senicapoc Inhibitor 99.83%
    Senicapoc 是一种有效的,具有选择性的 Gardos channel 抑制剂,IC50 值 11 nM;阻止人红细胞中 Ca2+ 诱导的铷流动,IC50 值为 11 nM;阻止红细胞脱水,IC50 值 30 nM.
  • HY-15551
    E-4031 Inhibitor 98.03%
    E-4031是抗心律失常剂苯磺酰胺,阻断ATP敏感性钾通道。
  • HY-15598
    20-HETE Inhibitor
    20-HETE(20-hydroxy Arachidonic Acid)是血管收缩剂,可去极化血管平滑肌。
  • HY-P1275
    Tertiapin-Q Inhibitor
    Tertiapin-Q 是一种高度选择性的 GIRK1/4 异二聚体和 ROMK1 (Kir1.1) 阻断剂。
  • HY-100321
    MCHr1 antagonist 2 Inhibitor
    MCHr1 antagonist 2 是一种黑色素聚集激素受体 1 (melanin concentrating hormone receptor 1) 拮抗剂,IC50 值为 65 nM;MCHr1 antagonist 2 同时抑制 hERG,在 IMR-32 细胞中,IC50 值为 4.0 nM。
  • HY-100238
    Antihistamine-1 Inhibitor
    Antihistamine-1 是能够渗透血脑屏障的 H1-抗组胺药 (Ki=6.9 nM), 它也是 CYP2D6hERG 通道的抑制剂,其 IC50 值分别为 5.4 和 0.8 μM。
  • HY-15206
    Glibenclamide Inhibitor >98.0%
    Glibenclamide(Glyburide)是磺酰脲类化合物,能调节胰岛素的产生。
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+hKv1.4 通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 NF-κB 活性和 COX-2 表达。
  • HY-B1140
    Diazoxide Activator 99.76%
    Diazoxide是一种ATP敏感性的钾离子通道激活剂; 可用于治疗高胰岛素血症。
  • HY-13519
    TRAM-34 Inhibitor 99.71%
    TRAM-34 是一种选择性的钙激活 K+ 通道 (IKCa1)阻断剂,Kd 为 20 nM。
  • HY-B0112
    Minoxidil Activator 99.84%
    Minoxidil(U 10858)是血管扩张剂,可做用于高血压和脱发。
  • HY-14188
    Amiodarone hydrochloride Inhibitor 99.82%
    Amiodarone is a lipophilic antiarrhythmic/antianginal drug which is able to influence the physicochemical status of biological lipid components.
  • HY-B0401
    Tolbutamide Inhibitor >98.0%
    Tolbutamide是第一代钾离子通道阻断剂,是磺酰脲类口服活性的降糖化合物。
  • HY-10015
    PAP-1 Inhibitor 99.69%
    PAP-1是Kv1.3电压门控的钾离子通道抑制剂,能抑制人效应记忆T细胞增殖,EC50为2 nM。
  • HY-B0232
    Dofetilide Inhibitor >98.0%
    Dofetilide(Tikosyn)是III型抗心律失常药,能阻断钾离子通道。
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor 99.31%
    Endoxifen Z-isomer hydrochloride盐酸盐是最重要的Tamoxifen代谢产物, 诱导在表达ERα的乳腺癌细胞中发挥抗雌激素作用, Endoxifen抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。
  • HY-17001
    Flupirtine Maleate Activator 99.97%
    Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。
  • HY-14183
    Vernakalant Hydrochloride Inhibitor 99.33%
    Vernakalant hydrochloride 是一种混合电压和频率依赖性的 Na+K+ 通道阻断剂。Vernakalant 抑制 Kv1.5 channelwtKv1.5 channelI508FKv1.5 channelT479AIC50 分别为 13.35±0.93 μM
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.