1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. YZ129

YZ129 

目录号: HY-114413
产品使用指南

YZ129 是 HSP90-磷酸酶-NFAT 通路的抑制剂,可抗胶质母细胞瘤,直接与 热休克蛋白 (HSP90) 结合,对NFAT核易位的 IC50 值为820 nM。YZ129 在 G2/M 期诱导GBM细胞周期阻滞,促进细胞凋亡,抑制肿瘤细胞增值和迁移。

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YZ129 Chemical Structure

YZ129 Chemical Structure

CAS No. : 1643120-60-8

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Description

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].

IC50 & Target[1]

HSP90

 

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

300.31

Formula

C₁₉H₁₂N₂O₂

CAS No.

1643120-60-8

SMILES

O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O

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Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
YZ129
目录号:
HY-114413
需求量:

YZ129

Cat. No.: HY-114413