1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

(+)-Dihydrexidine hydrochloride 

目录号: HY-101299
产品使用指南

(+)-Dihydrexidine hydrochloride 是一种多巴胺 D1 受体激动剂,EC50 为 72±21 nM。

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(+)-Dihydrexidine hydrochloride Chemical Structure

(+)-Dihydrexidine hydrochloride Chemical Structure

CAS No. : 158704-02-0

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Description

(+)-Dihydrexidine hydrochloride is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM.

IC50 & Target

EC50: 72±21 nM (Dopamine D1 receptor)[1]

In Vitro

(+)-Dihydrexidine hydrochloride (DHX) is a high-potency, bioavailable D1 dopamine receptor agonist. (+)-Dihydrexidine is screened for activity against 40 other binding sites, and is inactive (IC50 greater than 10 microM) against all except D2 dopamine receptors (IC50=130 nM) and alpha 2 adrenoreceptors (IC50=230 nM). Dihydrexidine competes stereoselectively and potently for D1 binding sites in rat striatal membranes labeled with [3H]SCH23390 with an IC50 of about 10 nM compared to about 30 nM for the prototypical D1 agonist SKF38393[2].

In Vivo

To examine the functional state of striatal neurons in response to D1 receptor activation, AC5+/+ and AC5-/- mice are injected with the D1 agonist (+)-Dihydrexidine (30 mg/kg, i.p.) and obtained the dorso-lateral striatum and NAc, separately, 45 min later for RT-PCR analysis. These experiments reveal that (+)-Dihydrexidine -triggered induction of the immediate early genes, c-fos, egr-1, and junB, in the NAc is markedly enhanced in AC5-/- mice compared with that in AC5+/+ mice, while the induction in the dorso-lateral striatum is suppressed in AC5-/- mice[3].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.2919 mL 16.4593 mL 32.9186 mL
5 mM 0.6584 mL 3.2919 mL 6.5837 mL
10 mM 0.3292 mL 1.6459 mL 3.2919 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[3]

Mice[3]
AC5-/- mice are backcrossed to the C57BL/6J strain for 9 or 10 generations to obtain heterozygote N9 or N10 mice. Mice are treated with (+)-Dihydrexidine (30 mg/kg, i.p.)[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

303.78

Formula

C₁₇H₁₈ClNO₂

CAS No.

158704-02-0

SMILES

OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
(+)-Dihydrexidine hydrochloride
目录号:
HY-101299
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