2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Abelacimab

Abelacimab  (Synonyms: MAA868)

目录号: HY-P99415 纯度: 98.63%
COA

摩尔计算器

Abelacimab (MAA868) 是一种全人源 IgG1 单克隆抗体，可高亲和力与 FXI 的催化结构域结合并将其锁定在酶原构象中，从而防止其被 FXIIa 或凝血酶激活。Abelacimab 可用于血栓栓塞性疾病研究。

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Abelacimab Chemical Structure

Abelacimab Chemical Structure

CAS No. : 2098724-83-3

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
10 mg   询价  
50 mg   询价  

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Customer Review

Abelacimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies[1][2].

体外研究
(In Vitro)

Abelacimab (MAA868) (0.0001-1 μM) 以浓度依赖的方式延长凝血时间并减少人血浆中的凝血酶数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Abelacimab 相关抗体:
体内研究
(In Vivo)

Abelacimab (MAA868) (s.c., 3-30 mg/kg, on day 1, 85, 114) 在食蟹猴中表现出强烈和持续的抗凝血作用，显着延长 aPTT，且具有较好的安全性，未观察到显着的毒性发现或出血迹象[1]。
Abelacimab (MAA868) (i.v., 0.6 mg/kg) 在氯化铁诱导的血栓形成 FXI-/- C57BL/6 小鼠模型中表现出良好的抗凝血活性，以防止颈动脉阻塞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.63%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Abelacimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abelacimab2098724-83-3MAA868MAA 868MAA-868Factor XaFxaFXIFXIIathrombinthromboembolicmonoclonal antibodyIgG1Inhibitorinhibitorinhibit

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