2. Apoptosis
  3. Necroptosis
  4. AG311

AG311 是一种抗癌和抗转移剂。AG311 诱导多种癌细胞快速坏死 (necrosis)。

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AG311 Chemical Structure

AG311 Chemical Structure

CAS No. : 1126602-42-3

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AG311 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines[1].

体外研究
(In Vitro)

AG311 (0-30 μM; 48 h) 显示对癌细胞的细胞毒性[1]。
AG311 (10-40 μM; 0-150 min) 选择性诱导乳腺癌细胞膜透性 (与 HUVECs 相比)[1]。
Ag311 (25 μm;20 min)诱导MDA-MB-435细胞坏死，缺乏凋亡分子标志物[1]。
AG311 (25 μM; 20 min) 影响 MDA-MB-435 细胞钙稳态和质膜去极化[1]。
AG311 (5-20 μM) 诱导 MDA-MB-435 细胞线粒体膜快速改变和线粒体功能障碍[1]。
AG311 (0-14 μM; 30 h) 抑制乳腺癌细胞迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AG311 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-435, MDA-MB-468, MDA-MB-231, MCF7, PANC-1, A375, U251, SH-SY5Y, A431, B16F10, COLO-205, DU145, HUVEC and HDF
Concentration:
Incubation Time: 48 h
Result: The IC50 value for MDA-MB-435 (BLBC) was 13.9 μM. In other breast cancer cell lines, had similar (MDA-MB-468 and MCF7) or lower (MDA-MB-231) IC50 values compared with MDAMB-435. was least potent on noncancerous human dermal fibroblasts HDF (IC50 29.3 μM), suggesting a level of selectivity.

Cell Migration Assay [1]

Cell Line: 4T1-luc2-GFP TNBC cells
Concentration: 0, 8, 10, 12, 14 μM
Incubation Time: 30 h
Result: Significantly inhibited cell migration at multiple subtoxic doses in 4T1-luc2-GFP cells.
体内研究
(In Vivo)

AG311 (23 mM; intratumoral; once daily for 2 days) 在小鼠中增加癌细胞坏死[1]。
AG311 (45 mg/kg; i.p.; twice weekly for 30 days) 抑制小鼠肿瘤生长和肺转移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/cJ mice, 4T1 Triple Negative Orthotopic Allograft[1]
Dosage: 23 mM, 1/15 of tumor volume
Administration: Intratumoral injection, once daily for 2 days
Result: Injected tumors had a significantly higher percentage of necrosis compared with their control-treated counterparts.
Animal Model: 7-week-old female NCr nu/nu athymic mice, MDA-MB-435 Orthotopic Xenograft[1]
Dosage: 45 mg/kg
Administration: Intraperitoneal injection, twice weekly for 30 days
Result: Significantly reduced primary tumor growth. Animals had fewer lung metastases at the end of the experiment compared with control-treated animals.
分子量

321.40

Formula

C17H15N5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AG311 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG3111126602-42-3AG 311AG-311NecroptosisMDA-MB-435MDA-MB-468MDA-MB-231MCF7PANC-1A375U251SH-SY5YA431B16F10COLO-205DU145Inhibitorinhibitorinhibit

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