2. Immunology/Inflammation
  3. COX
  4. α-​Chaconine

α-​Chaconine  (Synonyms: 阿尔法卡茄碱)

目录号: HY-129113 纯度: 99.04%
COA 产品使用指南

摩尔计算器

α-Chaconine 可在转录水平抑制 COX-2，IL-1β，IL-6 和 TNF-α 表达。α-Chaconine 作用于 RAW 264.7 巨噬细胞，在蛋白和 mRNA 水平上抑制 LPS 诱导的 iNOS 和 COX-2 表达及其启动子活性。α-Chaconine 具有抗炎作用。

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α-​Chaconine Chemical Structure

α-​Chaconine Chemical Structure

CAS No. : 20562-03-2

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规格 价格 是否有货 数量
1 mg ￥3500
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α-​Chaconine 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects[1].

IC50 & Target

COX-2

 

体外研究
(In Vitro)

α-Chaconine attenuates the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.α-Chaconine suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock.α-Chaconine also suppresses the phosphorylation of TGF-β-activated kinase-1 (TAK1), which lies upstream of MKK7/JNK signaling[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-​Chaconine 相关抗体:
分子量

852.06

Formula

C45H73NO14
CAS 号
性状

固体

颜色

White to off-white

中文名称

阿尔法卡茄碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

α-​Chaconine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-​Chaconine20562-03-2阿尔法卡茄碱COXCyclooxygenaseInflammatorymediatorCOX-2IL-1βIL-6TNF-αiNOSAP-1Inhibitorinhibitorinhibit

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目录号：
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